Last update Jan. 27, 2021
Enoxolone is a glycyrrhizinic acid derivative that is extracted from the root of licorice.
Anti-inflammatory effect when topically applied (skin, mouth, throat and rectum).
At latest update no published data on excretion into breast milk were found.
The small dose and poor plasma uptake of most topical oral and dermatological preparations make it very unlikely that significant amounts will pass into breast milk.
Systemic absorption of topical oral and dermatological enoxolone is minimal (Morikane 2020, AEMPS 2019).
Enoxolone enhances corticosteroid activity by inhibiting a cortisol-inactivating enzyme, so it can cause severe toxicity (elevation of sodium and reduction of potassium levels) after systemic administration (Omar 2012).
There is a case report of systemic toxicity following extensive topical use (Navarre 2002).
It can cause allergic contact dermatitis (Tanaka 2001).
It is not recommended a prolonged use of this product during lactation.
Avoid applying it on the breast, otherwise, clean it thoroughly before breastfeeding.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
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