Last update Dec. 28, 2023

Econazole

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Econazole is a topical imidazole antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. topical cutaneous administration.

At the time of the last update, we found no published data on its excretion in breast milk.

The very low plasma absorption of econazole through the skin or vagina, less than 1% (Alvogen 2017, Mactal 2001, Benziger 1983), makes passage of significant amount into breast milk very unlikely.

Expert authors consider the use of this drug safe during lactation. (Hale, LactMed, Briggs 2015, Leachman 2006)

Do not apply on nipple-areola or clean thoroughly before breastfeeding.

Alternatives

  • Clotrimazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Miconazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Econazole is also known as


Econazole in other languages or writings:

Tradenames

Main tradenames from several countries containing Econazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 445 daltons

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006 Abstract
  5. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  6. Benziger DP, Edelson J. Absorption from the vagina. Drug Metab Rev. 1983;14(2):137-68. Review. Abstract

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