Last update Jan. 17, 2024

Dopamine Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Dopamine is a sympathomimetic catecholamine used to treat hemodynamic imbalances, poor perfusion of vital organs, low cardiac output and hypotension arising from situations such as acute heart failure, cardiogenic shock, myocardial infarction, renal failure, cardiac surgery and septic shock. Intravenous infusion administration.

At the time of the last update, we found no published data on its excretion in breast milk.

Its very short elimination half-life (2 minutes) makes it very unlikely to pass into breast milk in significant quantities.


Its lack of oral bioavailability makes it difficult for it to pass into infant plasma from ingested breast milk, since it is degraded in the gastrointestinal tract and is not absorbed.

Dopamine inhibits prolactin release from the anterior pituitary (Fitzgerald 2008, Ben 2001), but once breastfeeding is established, milk secretion depends little on prolactin and there are no publications on dopamine and milk production.

Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

Alternatives

We do not have alternatives for Dopamine Hydrochloride.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dopamine Hydrochloride in other languages or writings:

Group

Dopamine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dopamine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 153 daltons
pKa 10.01 -
Tmax 0.08 hours
0.03 hours

References

  1. Fitzgerald P, Dinan TG. Prolactin and dopamine: what is the connection? A review article. J Psychopharmacol. 2008 Mar;22(2 Suppl):12-9. Abstract
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  3. Ben-Jonathan N, Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev. 2001 Dec;22(6):724-63. Review. Abstract

Total visits

8,625

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM