Last update June 26, 2023



Safe substance and/or breastfeeding is the best option.

Approved as an antiemetic and prokinetic in many countries, although not in the US (Hale 2018, Rowe 2013, Sachs 2013, Da Silva 2004) and often prescribed in young infants for the treatment of gastroesophageal reflux disease. Indicated for the control of nausea and vomiting. Oral administration 3 times a day.

It is excreted in breastmilk in clinically insignificant amount (Knoppert 2013, Wan 2008), even at doses as high as 160 mg daily (Krutsch 2023), and no problems have been recorded in infants whose mothers were taking it. (Krutsch 2023, Madjunkov 2017, Osadchy 2012, Da Silva 2001, Petraglia 1985)

Being a dopamine antagonist, it increases the production of prolactin (Wan 2008, Hofmeyr 1985, Petraglia 1985, Brouwers 1980) and of milk (Petraglia 1985), being able to produce galactorrhea (Poovathingal 2013, Cann 1983), so it is widely used as a galactogogue (Brodribb 2018, Rowe 2013, Grzeskowiak 2013, Anderson 2013, Winterfeld 2012, Anderson 2007, Da Silva 2004, Brown 2000). It does not cross the blood-brain barrier (Amir 2011, Gabay 2002, Hofmeyr 1985, Petraglia 1985, Brouwers 1980) as it has no neurological effects, so it would be preferable to metoclopramide for that purpose. (Hale 2018)

At a dose of 10 to 20 mg every 8 hours for 2 to 4 weeks, milk production increases, especially in mothers of preterm infants admitted to neonatal units (Shen 2021, Khorana 2021, Wada 2019, Taylor 2019, Asztalos 2019, Grzeskowiak 2018, Brodribb 2018, Asztalos 2017, Fazilla 2017, Haase 2016, Rai 2016, Bazzano 2016, Knoppert 2013, Donovan 2012, Ingram 2012, Osadchy 2012, Campbell 2010, Wan 2008, Da Silva 2001, Petraglia 1985, Hofmeyr 1983), after a cesarean section (Jantarasaengaram 2012) and in cases of relactation (Muresan 2011), lactation induction (Bryant 2006), breast hypoplasia (Duran 2011) and transgender women. (Wamboldt 2021, Reisman 2018)

There is little evidence of its efficacy as a galactogogue in mothers of full-term non-premature infants, and beyond the neonatal period (Foong 2020, McGuire 2018). Some studies show that it is not effective in all mothers (Wan 2008), that it may cease to be effective by the 4th week of its administration (Asztalos 2017), that there are no significant differences in the increase in milk production with 30 or 60 mg daily (Knoppert 2013), and that, despite the increase in milk production, there may be neither weight gain in breastfed infants (Rai 2016) nor decreased risk of breastfeeding cessation. (Grzeskowiak 2018).

Side effects in mothers are rare: abdominal pain, diarrhea, headache, mood swings, dizziness, depression and dry mouth (Suain 2022, McBride 2021, Wada 2019, Hale 2018, Ingram 2012, Jantarasaengaram 2012) and are more frequent at high doses or prolonged treatment. (Wan 2008)

Domperidone has been associated with an increased risk of severe ventricular arrhythmias in older people (Leelakanok 2016) or with previous cardiac abnormalities (lengthened QT on the ECG) or associated with medications that lengthen the QT (Doggrell 2014), being extraordinarily rare in healthy women of childbearing age (Moriello 2021, Hale 2018, Madjunkov 2017, Smolina 2016). Only one woman with a previous history of arrhythmia presented ventricular arrhythmia among the more than 200,000 treated with domperidone in the postpartum period. (Smolina 2016, Grzeskowiak 2018 & 2017)

In order to avoid withdrawal symptoms, as insomnia, anxiety/depressión/psychosis and tachycardia (Majdinasab 2022, Sharma 2021, Doyle 2018, Seeman 2015, Papastergiou 2013), it is advisable to carry out a slow progressive withdrawal over several weeks.

Domperidone increases the concentration of calcium in breastmilk without altering the caloric content or that of other components. (Campbell 2010)

The maternal perception of insufficient milk is one of the main reasons for cessation of breastfeeding (Grzeskowiak 2019, Winterfeld 2012, Jones 2011, Zuppa 2010, Amir 2006). The best galactogogue is effective support and advice during pregnancy and after childbirth to achieve breastfeeding on frequent demand and with correct technique in a mother who retains her self-confidence (Brodribb 2018, Anderson 2013, Mannion 2012, Forinash 2012, Comité 2012, ABM 2011, Jones 2011, Anderson 2007, Amir 2006, Seema 1999). Do not use as a galactogogue without health checks.

Several medical societies and expert consider the use of this medication to be safe or very probably safe during breastfeeding (Shen 2021, Grzeskowiak 2018, Hale 2018, Amir 2011, Zuppa 2010, Marasco 2008, Mahadevan 2006, Lee 1993). American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)


We do not have alternatives for Домперидон since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Домперидон is Domperidone in Cyrillic.

Is written in other languages:

Домперидон is also known as


Домперидон belongs to these groups or families:


Main tradenames from several countries containing Домперидон in its composition:


Variable Value Unit
Oral Bioavail. 15 - 20 %
Molecular weight 426 daltons
Protein Binding 91 - 93 %
VD 6 l/Kg
pKa 7.03 -
Tmax 0.5- 1 hours
7 - 9 hours
M/P ratio 0.25 - 0.6 -
Theoretical Dose 0.00004 - 0.001 mg/Kg/d
Relative Dose 0.004 - 0.1 %
Ped.Relat.Dose 0.016 - 0.4 %


  1. Krutsch K, Datta P. The Transfer of Domperidone into Human Milk Remains Low at High Doses. Breastfeed Med. 2023 Jul;18(7):555-556 Consulted on June 26, 2023 Abstract
  2. Majdinasab E, Haque S, Stark A, Krutsch K, Hale TW. Psychiatric Manifestations of Withdrawal Following Domperidone Used as a Galactagogue. Breastfeed Med. 2022 Nov 11. doi: 10.1089/bfm.2022.0190. PMID: 36367713. Consulted on Nov. 14, 2022 Abstract
  3. Suain Bon R, Mahmud AA. Domperidone Use as a Galactagogue and Infanticide Ideation: A Case Report. Breastfeed Med. 2022 Aug;17(8):698-701 Consulted on July 13, 2022 Abstract
  4. Shen Q, Khan KS, Du MC, Du WW, Ouyang YQ. Efficacy and Safety of Domperidone and Metoclopramide in Breastfeeding: A Systematic Review and Meta-Analysis. Breastfeed Med. 2021 Mar 25. Abstract
  5. Wamboldt R, Shuster S, Sidhu BS. Lactation Induction in a Transgender Woman Wanting to Breastfeed: Case Report. J Clin Endocrinol Metab. 2021 Jan 29. pii: dgaa976. Abstract Full text (link to original source)
  6. Khorana M, Wongsin P, Torbunsupachai R, Kanjanapattanakul W. Effect of Domperidone on Breast Milk Production in Mothers of Sick Neonates: A Randomized, Double-Blinded, Placebo-Controlled Trial. Breastfeed Med. 2021 Mar;16(3):245-250. Abstract
  7. Sharma V, Sharma S, Doobay M. Domperidone Withdrawal in a Nursing Female with Pre-existing Psychiatric Illness: Case Report. Curr Drug Saf. 2021 Oct 13. Abstract
  8. Moriello C, Paterson JM, Reynier P, Dahl M, Aibibula W, Fisher A, Gamble JM, Kuo IF, Ronksley PE, Winquist B, Filion KB; Canadian Network for Observational Drug Effect Studies (CNODES) Investigators.. Off-label postpartum use of domperidone in Canada: a multidatabase cohort study. CMAJ Open. 2021 May 14;9(2):E500-E509. Abstract
  9. McBride GM, Stevenson R, Zizzo G, Rumbold AR, Amir LH, Keir AK, Grzeskowiak LE. Use and experiences of galactagogues while breastfeeding among Australian women. PLoS One. 2021 Jul 1;16(7):e0254049. Abstract Full text (link to original source)
  10. Foong SC, Tan ML, Foong WC, Marasco LA, Ho JJ, Ong JH. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. Cochrane Database Syst Rev. 2020 May 18;5:CD011505. Abstract Full text (link to original source)
  11. Maged AM, Hassanin ME, Kamal WM, Abbassy AH, Alalfy M, Askalani AN, El-Lithy A, Nabil M, Farouk D, Hussein EA, Hammad B. Effect of Low-Level Laser Therapy versus Electroacupuncture on Postnatal Scanty Milk Secretion: A Randomized Controlled Trial. Am J Perinatol. 2020 Oct;37(12):1243-1249. Abstract
  12. Asztalos EV, Kiss A, daSilva OP, Campbell-Yeo M, Ito S, Knoppert D; <italic>EMPOWER</italic> Study Collaborative Group.. Evaluating the Effect of a 14-Day Course of Domperidone on Breast Milk Production: A Per-Protocol Analysis from the EMPOWER Trial. Breastfeed Med. 2019 Mar;14(2):102-107. Abstract Full text (link to original source)
  13. Asztalos EV, Kiss A, daSilva OP, Campbell-Yeo M, Ito S, Knoppert D; EMPOWER Study Collaborative Group.. Role of days postdelivery on breast milk production: a secondary analysis from the EMPOWER trial. Int Breastfeed J. 2019 Jun 4;14:21. Abstract
  14. Grzeskowiak LE, Wlodek ME, Geddes DT. What Evidence Do We Have for Pharmaceutical Galactagogues in the Treatment of Lactation Insufficiency?-A Narrative Review. Nutrients. 2019 Apr 28;11(5). pii: E974. Abstract Full text (link to original source)
  15. Wada Y, Suyama F, Sasaki A, Saito J, Shimizu Y, Amari S, Ito Y, Sago H. Effects of Domperidone in Increasing Milk Production in Mothers with Insufficient Lactation for Infants in the Neonatal Intensive Care Unit. Breastfeed Med. 2019 Dec;14(10):744-747. Abstract
  16. Asztalos EV, Kiss A, daSilva OP, Campbell-Yeo M, Ito S, Knoppert D; EMPOWER Study Collaborative Group. Evaluating the Effect of a 14-Day Course of Domperidone on Breast Milk Production: A Per-Protocol Analysis from the EMPOWER Trial. Breastfeed Med. 2019 Mar;14(2):102-107. Abstract
  17. Taylor A, Logan G, Twells L, Newhook LA. Human Milk Expression After Domperidone Treatment in Postpartum Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Hum Lact. 2019 Aug;35(3):501-509. Abstract
  18. Grzeskowiak LE, Amir LH, Smithers LG. Longer-term breastfeeding outcomes associated with domperidone use for lactation differs according to maternal weight. Eur J Clin Pharmacol. 2018 Abstract
  19. Grzeskowiak LE, Smithers LG, Amir LH, Grivell RM. Domperidone for increasing breast milk volume in mothers expressing breast milk for their preterm infants: a systematic review and meta-analysis. BJOG. 2018 Abstract
  20. Doyle M, Grossman M. Case report: domperidone use as a galactagogue resulting in withdrawal symptoms upon discontinuation. Arch Womens Ment Health. 2018 Abstract
  21. Hale TW, Kendall-Tackett K, Cong Z. Domperidone versus metoclopramide: Self-reported side effects in a large sample of breastfeeding mothers who used these medications to increase milk production. Clin Lact. 2018;9:10–7. Abstract Full text (link to original source)
  22. McGuire TM. Drugs affecting milk supply during lactation. Aust Prescr. 2018 Feb;41(1):7-9. Abstract Full text (link to original source)
  23. Reisman T, Goldstein Z. Case Report: Induced Lactation in a Transgender Woman. Transgend Health. 2018 Jan 1;3(1):24-26. Abstract Full text (link to original source) Full text (in our servers)
  24. ABM: Brodribb W. ABM Clinical Protocol #9: Use of Galactogogues in Initiating or Augmenting Maternal Milk Production, Second Revision 2018. Breastfeed Med. 2018 Jun;13(5):307-314 Abstract Full text (link to original source) Full text (in our servers)
  25. Madjunkov M, Chaudhry S, Fujioka I, Pfaller-Eiwegger B, Newman J, Ito S. Safety of domperidone as a galactogogue: A retrospective chart review study. In 30th Annual Education Meeting for Organization of Teratology Information Specialists Members and MotherToBaby Affiliates. Birth Defects Res. 2017;109 (SI):712, Poster 10. 2017
  26. Fazilla TE, Tjipta GD, Ali M, Sianturi P. Domperidone and maternal milk volume in mothers of premature newborns. Paediatr Indones. 2017;57:18–22. Full text (link to original source)
  27. Grzeskowiak LE. Domperidone for Lactation: What Health Care Providers Really Should Know. Obstet Gynecol. 2017 Abstract
  28. Asztalos EV, Campbell-Yeo M, da Silva OP, Ito S, Kiss A, Knoppert D; EMPOWER Study Collaborative Group.. Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants. J Hum Lact. 2017 Abstract
  29. Haase B, Taylor SN, Mauldin J, Johnson TS, Wagner CL. Domperidone for Treatment of Low Milk Supply in Breast Pump-Dependent Mothers of Hospitalized Premature Infants: A Clinical Protocol. J Hum Lact. 2016 Abstract
  30. Leelakanok N, Holcombe A, Schweizer ML. Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis. Clin Drug Investig. 2016 Abstract
  31. Bazzano AN, Hofer R, Thibeau S, Gillispie V, Jacobs M, Theall KP. A Review of Herbal and Pharmaceutical Galactagogues for Breast-Feeding. Ochsner J. 2016 Abstract Full text (link to original source) Full text (in our servers)
  32. Smolina K, Mintzes B, Hanley GE, Oberlander TF, Morgan SG. The association between domperidone and ventricular arrhythmia in the postpartum period. Pharmacoepidemiol Drug Saf. 2016 Abstract
  33. Rai R, Mishra N, Singh DK. Effect of Domperidone in 2nd week Postpartum on Milk Output in Mothers of Preterm Infants. Indian J Pediatr. 2016 Abstract
  34. Seeman MV. Transient psychosis in women on clomiphene, bromocriptine, domperidone and related endocrine drugs. Gynecol Endocrinol. 2015 Abstract
  35. Doggrell SA, Hancox JC. Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine. Expert Opin Drug Saf. 2014 Abstract
  36. Poovathingal MA, Bhat R, Ramamoorthi. Domperidone induced galactorrhea: an unusual presentation of a common drug. Indian J Pharmacol. 2013 May-Jun;45(3):307-8. Abstract Full text (link to original source)
  37. Worthington I, Pringsheim T, Gawel MJ, Gladstone J, Cooper P, Dilli E, Aube M, Leroux E, Becker WJ; Canadian Headache Society Acute Migraine Treatment Guideline Development Group. Canadian Headache Society Guideline: acute drug therapy for migraine headache. Can J Neurol Sci. 2013 Sep;40(5 Suppl 3):S1-S80. Review. Abstract Full text (in our servers)
  38. Knoppert DC, Page A, Warren J, Seabrook JA, Carr M, Angelini M, Killick D, Dasilva OP. The effect of two different domperidone doses on maternal milk production. J Hum Lact. 2013 Abstract
  39. Grzeskowiak LE, Lim SW, Thomas AE, Ritchie U, Gordon AL. Audit of domperidone use as a galactogogue at an Australian tertiary teaching hospital. J Hum Lact. 2013 Abstract
  40. Anderson PO. The galactogogue bandwagon. J Hum Lact. 2013 Abstract
  41. Papastergiou J, Abdallah M, Tran A, Folkins C. Domperidone withdrawal in a breastfeeding woman. Can Pharm J (Ott). 2013 Abstract Full text (link to original source) Full text (in our servers)
  42. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  43. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  44. Bozzo P, Koren G, Ito S. Health Canada advisory on domperidone should I avoid prescribing domperidone to women to increase milk production [corrected]? Can Fam Physician. 2012 Abstract Full text (in our servers)
  45. Winterfeld U, Meyer Y, Panchaud A, Einarson A. Management of deficient lactation in Switzerland and Canada: a survey of midwives' current practices. Breastfeed Med. 2012 Aug;7:317-8. Abstract
  46. Ingram J, Taylor H, Churchill C, Pike A, Greenwood R. Metoclopramide or domperidone for increasing maternal breast milk output: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2012 Abstract
  47. Forinash AB, Yancey AM, Barnes KN, Myles TD. The use of galactogogues in the breastfeeding mother. Ann Pharmacother. 2012 Oct;46(10):1392-404. Abstract
  48. Jantarasaengaram S, Sreewapa P. Effects of domperidone on augmentation of lactation following cesarean delivery at full term. Int J Gynaecol Obstet. 2012 Abstract
  49. Mannion C, Mansell D. Breastfeeding self-efficacy and the use of prescription medication: a pilot study. Obstet Gynecol Int. 2012;2012:562704. Abstract Full text (link to original source) Full text (in our servers)
  50. Donovan TJ, Buchanan K. Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants. Cochrane Database Syst Rev. 2012 Abstract
  51. Osadchy A, Moretti ME, Koren G. Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials. Obstet Gynecol Int. 2012 Abstract Full text (link to original source) Full text (in our servers)
  52. Asztalos EV, Campbell-Yeo M, daSilva OP, Kiss A, Knoppert DC, Ito S. Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial). BMC Pregnancy Childbirth. 2012 Abstract Full text (link to original source) Full text (in our servers)
  53. CLM - Comité de Lactancia Materna de la AEP. Preguntas frecuentes sobre lactancia materna. Folleto. 2012 Full text (link to original source) Full text (in our servers)
  54. ABM. Comité de Protocolos de la Academia Médica de Lactancia Materna. ABM Protocolo Clínico #9: Uso de Galactogogos para Iniciar o aumentar la tasa de secreción de Leche Materna. Breastfeed Med. 2011 Full text (link to original source) Full text (in our servers)
  55. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  56. Duran MS, Spatz DL. A mother with glandular hypoplasia and a late preterm infant. J Hum Lact. 2011 Abstract
  57. ABM. Academy Of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #9: Use of galactogogues in initiating or augmenting the rate of maternal milk secretion (First Revision January 2011). Breastfeed Med. 2011 Abstract Full text (link to original source) Full text (in our servers)
  58. Muresan M. Successful relactation--a case history. Breastfeed Med. 2011 Abstract
  59. Jones W, Breward S. Use of domperidone to enhance lactation: what is the evidence? Community Pract. 2011 Abstract
  60. Szucs KA, Axline SE, Rosenman MB. Induced lactation and exclusive breast milk feeding of adopted premature twins. J Hum Lact. 2010 Aug;26(3):309-13. Abstract
  61. Zuppa AA, Sindico P, Orchi C, Carducci C, Cardiello V, Romagnoli C. Safety and efficacy of galactogogues: substances that induce, maintain and increase breast milk production. J Pharm Pharm Sci. 2010;13(2):162-74. Abstract Full text (link to original source) Full text (in our servers)
  62. Campbell-Yeo ML, Allen AC, Joseph KS, Ledwidge JM, Caddell K, Allen VM, Dooley KC. Effect of domperidone on the composition of preterm human breast milk. Pediatrics. 2010 Abstract Full text (in our servers)
  63. Wan EW, Davey K, Page-Sharp M, Hartmann PE, Simmer K, Ilett KF. Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk. Br J Clin Pharmacol. 2008 Abstract Full text (link to original source) Full text (in our servers)
  64. Marasco L. Inside track. Increasing your milk supply with galactogogues. J Hum Lact. 2008 Abstract
  65. Anderson PO, Valdés V. A critical review of pharmaceutical galactagogues. Breastfeed Med. 2007 Abstract
  66. Bryant CA. Nursing the adopted infant. J Am Board Fam Med. 2006 Abstract Full text (link to original source) Full text (in our servers)
  67. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  68. Amir LH. Breastfeeding--managing 'supply' difficulties. Aust Fam Physician. 2006 Abstract Full text (link to original source) Full text (in our servers)
  69. da Silva OP, Knoppert DC. Domperidone for lactating women. CMAJ. 2004 Abstract Full text (in our servers)
  70. Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact. 2002 Aug;18(3):274-9. Abstract
  71. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  72. da Silva OP, Knoppert DC, Angelini MM, Forret PA. Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial. CMAJ. 2001 Abstract Full text (in our servers)
  73. Brown TE, Fernandes PA, Grant LJ, Hutsul JA, McCoshen JA. Effect of parity on pituitary prolactin response to metoclopramide and domperidone: implications for the enhancement of lactation. J Soc Gynecol Investig. 2000 Abstract
  74. Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993 Jul;48(7):616-25. Review. Abstract Full text (link to original source) Full text (in our servers)
  75. Hofmeyr GJ, Van Iddekinge B, Blott JA. Domperidone: secretion in breast milk and effect on puerperal prolactin levels. Br J Obstet Gynaecol. 1985 Abstract
  76. Petraglia F, De Leo V, Sardelli S, Pieroni ML, D'Antona N, Genazzani AR. Domperidone in defective and insufficient lactation. Eur J Obstet Gynecol Reprod Biol. 1985 Abstract
  77. Hofmeyr GJ, van Iddekinge B. Domperidone and lactation. Lancet. 1983 Abstract
  78. Cann PA, Read NW, Holdsworth CD. Galactorrhoea as side effect of domperidone. Br Med J (Clin Res Ed). 1983 Abstract Full text (in our servers)
  79. Brouwers JR, Assies J, Wiersinga WM, Huizing G, Tytgat GN. Plasma prolactin levels after acute and subchronic oral administration of domperidone and of metoclopramide: a cross-over study in healthy volunteers. Clin Endocrinol (Oxf). 1980 Abstract

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