Last update Sept. 5, 2022
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Доксициклин is Doxycycline in Cyrillic.Is written in other languages:
Доксициклин is also known as
Доксициклин belongs to these groups or families:
Main tradenames from several countries containing Доксициклин in its composition:
|Oral Bioavail.||90 - 100||%|
|Tmax||2 - 3||hours|
|T½||18 - 22||hours|
|M/P ratio||0.3 - 0.4||-|
|Theoretical Dose||0.12 - 0.29||mg/Kg/d|
|Relative Dose||7.2 - 17.4||%|
|Ped.Relat.Dose||6 - 14.5||%|
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Indicated in the treatment of infections caused by Mycoplasma pneumoniae, Chlamydia, Rickettsia and spirochetes. Oral administration once a day.
It is excreted into breast milk in quantities that would be clinically significant (Matsuda 1984, Lutziger 1969, Morganti 1968), however, theoretically, intestinal absorption by infant's gut is hampered because of formation of chelating products by union with the milk's calcium. (Chin 2001)
There are no studies that have evaluated dental staining in infants exposed to doxycycline through breastfeeding. (Wormser 2019)
Tetracycline is at lesser amount excreted into breast milk and at higher proportion bound to calcium, hence, it is fewer absorbed than Doxycycline. (Hale, Saito 2018, Chin 2001)
Long-term treatments are not recommended (over 3-4 weeks) since it may cause damage of the growth cartilage, teeth discoloration and imbalance of intestinal flora.
Several medical societies, experts and expert consensus, consider the use of this medication safe or probably safe during breastfeeding, especially if its use does not exceed 3-4 weeks. (Hale, Peyriere 2018, Briggs 2015, Rowe 2013, Chen 2010, Mitrano 2009, Nahum 2006, Mahadevan 2006, WHO 2002, Chin 2001)
Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Briggs 2015, Ito 1993)