Доксициклин

Indicated in the treatment of infections caused by Mycoplasma pneumoniae, Chlamydia, Rickettsia and spirochetes. Oral administration once a day.

It is excreted into breast milk in quantities that would be clinically significant ^{(Matsuda 1984, Lutziger 1969, Morganti 1968)}, however, theoretically, intestinal absorption by infant's gut is hampered because of formation of chelating products by union with the milk's calcium. ^{(Chin 2001)}

There are no studies that have evaluated dental staining in infants exposed to doxycycline through breastfeeding. ^{(Wormser 2019)}

Tetracycline is at lesser amount excreted into breast milk and at higher proportion bound to calcium, hence, it is fewer absorbed than Doxycycline^{. (Hale, Saito 2018, Chin 2001)}

Long-term treatments are not recommended (over 3-4 weeks) since it may cause damage of the growth cartilage, teeth discoloration and imbalance of intestinal flora.

Several medical societies, experts and expert consensus, consider the use of this medication safe or probably safe during breastfeeding, especially if its use does not exceed 3-4 weeks. ^{(Hale, Peyriere 2018, Briggs 2015, Rowe 2013, Chen 2010, Mitrano 2009, Nahum 2006, Mahadevan 2006, WHO 2002, Chin 2001)}

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. ^{(Briggs 2015, Ito 1993)}