Last update Nov. 14, 2022

Diphteria Antitoxin

Compatible

Safe product and/or breastfeeding is the best option.

They are specific antitoxic immunoglobulins that neutralize the Corynebacterium diphtheriae toxin. These are antibodies obtained from the serum of horses or other mammals hyperimmunized with diphtheria toxoid. It is used in the treatment of diphtheria. Single dose intravenous administration.

At the date of the last update, we found no published data on its excretion in breast milk.

The high molecular weight of the antibodies (Rothen 1942, Northrop 1942, Pappenheimer 1940) make it highly unlikely that significant quantities will pass into breast milk.

Due to its protein nature, it deteriorates in the gastrointestinal tract, not being absorbed. This low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk.

The possibility of breastfeeding during maternal diphtheria is conditioned by the severity of the disease.

Alternatives

We do not have alternatives for Diphteria Antitoxin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Diphteria Antitoxin is also known as


Diphteria Antitoxin in other languages or writings:

Group

Diphteria Antitoxin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Diphteria Antitoxin in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 90.000 - 150.000 daltons
T½ 117 ± 45 hours

References

  1. Smith HL, Saia G, Lobikin M, Tiwari T, Cheng SC, Molrine DC. Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria. Hum Vaccin Immunother. 2017 Nov 2;13(11):2738-2741. Abstract Full text (link to original source)
  2. Northrop JH. PURIFICATION AND CRYSTALLIZATION OF DIPHTHERIA ANTITOXIN. J Gen Physiol. 1942 Jan 20;25(3):465-85. Abstract Full text (link to original source)
  3. Rothen A. PURIFIED DIPHTHERIA ANTITOXIN IN THE ULTRACENTRIFUGE AND IN THE ELECTROPHORESIS APPARATUS. J Gen Physiol. 1942 Jan 20;25(3):487-96. Abstract Full text (link to original source)
  4. Pappenheimer AM, Lundgren HP, Williams JW. STUDIES ON THE MOLECULAR WEIGHT OF DIPHTHERIA TOXIN, ANTITOXIN, AND THEIR REACTION PRODUCTS. J Exp Med. 1940 Jan 31;71(2):247-62. Abstract Full text (link to original source)

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