Last update May 8, 2018

Dimemorfan Phosphate

Compatible

Safe substance and/or breastfeeding is the best option.

Centrally-acting non-narcotic antitussive, chemically related to codeine but devoid of central depressant effects (AEMPS 2014, Ida 1997).
Chemically similar to dextromethorphan (Shin 2011).
Administered orally 3 times a day.
A product which has very few bibliographical references.

Since the last update, we have not found published data on its excretion in breast milk.

Its use is authorized in infants from 6 months of age.

Given its lack of sedative effects, use at a sufficient minimum dose and for non-prolonged periods would have low risk during breastfeeding.

As there is less published experience than with other drugs from the same group, safer known alternatives may be preferable during the neonatal period and in case of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dimemorfan Phosphate in other languages or writings:

Group

Dimemorfan Phosphate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dimemorfan Phosphate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 353 daltons
Tmax 2.8 - 4 hours
11 hours

References

  1. Shen Y, Luo Z, Yu Q, Wang Y, Xiang J, Miao J. Pharmacokinetics of dimemorfan phosphate tablets in healthy Chinese volunteers. Eur J Clin Pharmacol. 2017 Abstract
  2. AEMPS. Dimemorfano (Dastosin). Ficha técnica. 2014 Full text (in our servers)
  3. Shin EJ, Bach JH, Lee SY, Kim JM, Lee J, Hong JS, Nabeshima T, Kim HC. Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs. J Pharmacol Sci. 2011 Abstract
  4. Ida H. The nonnarcotic antitussive drug dimemorfan: a review. Clin Ther. 1997 Abstract

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