Last update Oct. 28, 2014


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Salicylic acid derivative which is excreted into breast milk in low amount after an outdated source.

Known safer alternatives would be preferred.


We do not have alternatives for Diflunisal.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Diflunisal belongs to this group or family:


Main tradenames from several countries containing Diflunisal in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 250 daltons
Protein Binding 99 %
VD 0.1 - 0.2 l/Kg
Tmax 2 - 3 hours
8 - 12 hours
M/P ratio 0.02 - 0.07 -
Theoretical Dose 0.41 mg/Kg/d
Relative Dose 2.5 %


  1. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  2. Steelman SL, Breault GO, Tocco D et al. Pharmacokinetics of MK-647, a novel salicylate. Clin Pharmacol Ther. 1975;17:245. Abstract. 1975

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