Last update Sept. 3, 2022

Difenidol Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is an antiemetic agent used in the treatment of nausea and vomiting and vertigo in Ménière’s disease. Administered orally, intramuscularly or intravenously.

Since the last update we have not found published data on its excretion in breast milk.

The scarcity of known pharmacokinetic data does not allow to predict the magnitude of its possible excretion in breast milk.

It has a weak antimuscarinic action that could have negative effects on milk production in the first weeks postpartum.

There is very little literature on this drug and it is sold in very few countries.

It can cause severe symptoms at high doses. (Yang 1998, JAMA 1968).

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

If used during breastfeeding, a minimum effective dose is recommended for a limited time, monitoring for signs of irritability or drowsiness in the infant.

See below the information of this related product:


  • Metoclopramide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ondansetron ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Difenidol Hydrochloride is also known as

Difenidol Hydrochloride in other languages or writings:


Difenidol Hydrochloride belongs to these groups or families:


Main tradenames from several countries containing Difenidol Hydrochloride in its composition:


Variable Value Unit
Molecular weight 346 daltons
Tmax 1.5 - 3 hours
4 hours


  1. Zhang L, Ma J, Li S, Xue R, Jin M, Zhou Y. Fatal diphenidol poisoning: a case report and a retrospective study of 16 cases. Forensic Sci Med Pathol. 2015 Abstract
  2. Pan W, Liu Y, Huang Y, Yao S. Determination of difenidol hydrochloride by capillary electrophoresis with electrochemiluminescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Abstract
  3. Saval. Difenidol. Ficha técnica 2000 Full text (in our servers)
  4. Drugs. Difenidol. Drug Summary. 1999 Full text (link to original source) Full text (in our servers)
  5. Yang CC, Deng JF. Clinical experience in acute overdosage of diphenidol. J Toxicol Clin Toxicol. 1998 Abstract
  6. [No authors listed] Evaluation of a new antiemetic agent. Diphenidol (Vontrol). JAMA. 1968 Abstract
  7. Marano MJ. Treatment of nausea and vomiting in children with diphenidol. J Med Soc N J. 1967 Abstract

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