Last update Jan. 6, 2021



Safe substance and/or breastfeeding is the best option.

Penicillin that is resistant to staphylococcal penicillinase.
Administered orally or intravenously every 6 hours.

Like most penicillins (Nau 1987) it is excreted through breast milk in clinically insignificant amounts (Muysson 2020, Matsuda 1984) therefore there is no published data or even the expectation that problems could arise on the breastfeeding infants of mothers because of taking this drug

Widely used in the treatment of mastitis due to its excellent antibiotic activity against
Staphylococcus that are resistant to benzylpenicillin (Amir 2014 y 2011, Spencer 2008, Nordeng 2003, Bodley 2000).

The possibility of transitory gastroenteritis due to intestinal microbiome disruption should be taken into account (Briggs 2017, Ito 1993).


We do not have alternatives for Dicloxacillin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dicloxacillin is also known as

Dicloxacillin in other languages or writings:


Dicloxacillin belongs to this group or family:


Main tradenames from several countries containing Dicloxacillin in its composition:


Variable Value Unit
Oral Bioavail. 35 - 76 %
Molecular weight 470 daltons
Protein Binding 95 - 99 %
Tmax 1 - 1.5 hours
0.5 - 1 hours
Theoretical Dose 0.008 - 0.045 mg/Kg/d
Relative Dose 0.03 - 0.5 %
Ped.Relat.Dose 0.02 - 0.1 %


  1. Muysson M, Datta P, Rewers-Felkins K, Baker T, Hale TW. Transfer of Dicloxacillin into Human Milk. Breastfeed Med. 2020 Nov;15(11):715-717. Abstract
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Amir LH. y el Comité de protocolos de la Academy of Breastfeeding Medicine. Protocolo clínico de la ABM n.o 4: Mastitis, modi cado en marzo de 2014. Breastfeed Med. 2014;9(5):239-243. Abstract Full text (link to original source) Full text (in our servers)
  4. Amir LH; Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #4: Mastitis, Revised March 2014. Breastfeed Med. 2014;9(5):239-243. Abstract Full text (link to original source) Full text (in our servers)
  5. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  6. Spencer JP. Management of mastitis in breastfeeding women. Am Fam Physician. 2008 Abstract Full text (link to original source) Full text (in our servers)
  7. Nordeng H, Tufte E, Nylander G. [Treatment of mastitis in general practice]. Tidsskr Nor Laegeforen. 2003 Abstract
  8. Bodley V, Powers D. Case management of a breastfeeding mother with persistent oversupply and recurrent breast infections. J Hum Lact. 2000 Abstract
  9. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  10. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at

e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM