Last update July 15, 2015

Deflazacort

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Drug which is oxazolinic-derived from Prednisolone with similar properties to the latter.

At latest update no published data on excretion into breast milk were found.

Due to a moderate high molecular weight and rapid elimination time it is probably safe while breastfeeding, mostly in non long-term treatments.
Until more data on this drug is available, it would be preferred other options that are known to be safer, specially during the neonatal period and prematurity.

Alternatives

  • Prednisolone (Safe substance and/or breastfeeding is the best option.)
  • Prednisone (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Deflazacort is also known as


Deflazacort in other languages or writings:

Group

Deflazacort belongs to this group or family:

Tradenames

Main tradenames from several countries containing Deflazacort in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 68 %
Molecular weight 442 daltons
Protein Binding 40 %
Tmax 1.5 - 2 hours
T½ 1 - 2 hours

References

  1. eMC. Deflazacort. Drug Summary 2015 Full text (in our servers)
  2. AEMPS. Deflazacort. Ficha técnica. 2010 Full text (in our servers)
  3. Möllmann H, Hochhaus G, Rohatagi S, Barth J, Derendorf H. Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharm Res. 1995 Abstract
  4. Barbieri C, Baruto C, Sala M, Bigatti G, Parodi M, Bellini P, Bevilacqua M. Lack of effect of deflazacort, a novel glucocorticoid, on basal and TRH-stimulated prolactin and thyrotropin levels in healthy subjects. Eur J Clin Pharmacol. 1985 Abstract

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