Last update Nov. 4, 2022
Limited compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Dasatinib in other languages or writings:
Dasatinib belongs to these groups or families:
Main tradenames from several countries containing Dasatinib in its composition:
Variable | Value | Unit |
---|---|---|
Molecular weight | 488 | daltons |
Protein Binding | 93 - 96 | % |
VD | 35.8 | l/Kg |
pKa | 10.99 | - |
Tmax | 0.5 - 6 | hours |
T½ | 3 - 5 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Inhibitor of BCR-ABL and SRC tyrosine kinase that is used for treatment of Chronic Myeloid Leukemia and acute lymphoblastic leukaemia with Philadelphia chromosome-positive. Oral administration once daily.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic characteristics (very high plasma protein binding, very large volume of distribution, short half-life and moderately elevated molecular weight) make it very unlikely its excretion into breast milk in significant amounts.
No problems were reported in an infant of a mother treated during breastfeeding. (Alizadeh 2015)
The most common adverse effects of dasatinib include fluid retention, gastrointestinal disturbances, thrombocytopenia, and bleeding. (Martindale)
It is known from pharmacokinetics that after 3 elimination half-lives (T½) 87.5% of the drug is eliminated from the body; after 4 T½ it is 94%, after 5 T½, 96.9%, after 6 T½, 98.4% and after 7 T½ it is 99%. From 7 T½ the plasma concentrations of the drug in the body are negligible. In general, a period of at least five half-lives can be considered a safe waiting period before breastfeeding again.(Anderson 2016).
Taking the longest T½ published as a reference (5 hours), these 5 T½ would correspond to 25 hours (1 day). Meanwhile, express and discard milk from the breast regularly. This does not allow breastfeeding during treatment.
Abrupt weaning can be psychologically traumatic for both the mother and the infant. (Pistilli 2013).
Until more published data is known about this drug in relation to breastfeeding, better known alternatives may be preferable, especially during the neonatal period and in the event of prematurity.
If used during lactation, it is advisable to monitor growth and appetite and the possible appearance of diarrhea in the infant, as well as monitor hematological function periodically.
Given the strong evidence that exists regarding the benefits of breastfeeding for the development of babies and the health of mothers, it is advisable to evaluate the risk-benefit of any maternal treatment, including chemotherapy, individually advising each mother who wishes to continue with breastfeeding. (Koren 2013)
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