Last update Aug. 21, 2014

Dasatinib

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Inhibitor of BCR-ABL and SRC tyrosine kinase that is used for treatment of Chronic Myeloid Leukemia with positive Philadelphia chromosome.

At latest update, relevant published data on excretion into breast milk were not found.

Because of high serum protein-binding capacity, excretion into breast milk in significant amount is seemingly unlikely.

If continuation of safely breastfeeding is desired without assuming high risk for potentially severe side-effects, elimination of total burden of drug should be kept. For this to happen, breastfeeding should be stopped for 10 half-lives (T ½).

It means wait two and a half days after last dose before resuming breastfeeding.

Meanwhile, frequent pump-and-dump is recommended for maintenance of milk production.

Alternatives

We do not have alternatives for Dasatinib.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dasatinib is also known as


Group

Dasatinib belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dasatinib in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 488 daltons
Protein Binding 93 - 96 %
VD 35.8 l/Kg
Tmax 0.5 - 6 hours
3 - 6 hours

References

  1. PDR.net Dasatinib. Drug Summary. 2014 Full text (link to original source) Full text (in our servers)
  2. Argiris A, Feinstein TM, Wang L, Yang T, Agrawal S, Appleman LJ, Stoller RG, Grandis JR, Egloff AM. Phase I and pharmacokinetic study of dasatinib and cetuximab in patients with advanced solid malignancies. Invest New Drugs. 2012 Abstract
  3. Di Gion P, Kanefendt F, Lindauer A, Scheffler M, Doroshyenko O, Fuhr U, Wolf J, Jaehde U. Clinical pharmacokinetics of tyrosine kinase inhibitors: focus on pyrimidines, pyridines and pyrroles. Clin Pharmacokinet. 2011 Abstract
  4. EMEA Dasatinib Ficha técnica 2011 Full text (in our servers)
  5. Christopher LJ, Cui D, Wu C, Luo R, Manning JA, Bonacorsi SJ, Lago M, Allentoff A, Lee FY, McCann B, Galbraith S, Reitberg DP, He K, Barros A Jr, Blackwood-Chirchir A, Humphreys WG, Iyer RA. Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos. 2008 Abstract

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