Last update July 14, 2015

Colistin

Compatible

Safe substance and/or breastfeeding is the best option.

Pharmacokinetic data (high volume of distribution and molecular weight) would explain the minimal excretion into breast milk mentioned in two older reports.

Due to a poor oral bioavailability, appearance in the infant's plasma from ingested milk is regarded as nil or scanty, except in premature infants or during the immediate neonatal period who may show an increased intestinal absorption.

Alternatives

We do not have alternatives for Colistin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Colistin is also known as


Groups

Colistin belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Colistin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 1750 daltons
Protein Binding 50 %
VD 190 l/Kg
Tmax 1 - 7 hours
T½ 1.5 - 4 hours
M/P ratio 0.2 -
Theoretical Dose < 0.17 mg/Kg/d
Relative Dose < 3 %
Ped.Relat.Dose < 3 %

References

  1. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  2. LactMed. Colisitn. Full Record Display. 2015 Full text (in our servers)
  3. José de Jesús Coria Lorenzo, Alfredo Morayta Ramírez, Yetzamin Gutiérrez Muñoz. Polimixinas en la era de la multidrogorresistencia. Revista de Enfermedades Infecciosas en Pediatría 2011;25(98):66-70. 2011 Full text (in our servers)
  4. Luque S, Grau S, Berenguer N, Horcajada JP, Sorlí L, Montero MM, Salas E. [Shedding light on the use of colistin: still gaps to be filled]. Enferm Infecc Microbiol Clin. 2011 Abstract Full text (in our servers)
  5. Ratjen F, Rietschel E, Kasel D, Schwiertz R, Starke K, Beier H, van Koningsbruggen S, Grasemann H. Pharmacokinetics of inhaled colistin in patients with cystic fibrosis. J Antimicrob Chemother. 2006 Abstract
  6. Li J, Coulthard K, Milne R, Nation RL, Conway S, Peckham D, Etherington C, Turnidge J. Steady-state pharmacokinetics of intravenous colistin methanesulphonate in patients with cystic fibrosis. J Antimicrob Chemother. 2003 Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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