Last update March 26, 2020

Cobicistat

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Inhibidor selectivo de la isoenzima CYP3A del citocromo P450.
Aunque es, estructuralmente, un análogo del ritonavir, carece de acción antirretroviral en sí mismo. Se utiliza, al igual que el ritonavir, como potenciador farmacocinético para aumentar la biodisponibilidad y la semivida de eliminación de antirretrovirales como el atazanavir, el darunavir y el elvitegravir.
Se ha empleado de modo experimental, asociado a Darunavir, en el tratamiento de la infección por coronavirus COVID-19 (SEFH 2020).
Administración oral una vez al día.

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

Sus datos farmacocinéticos (muy amplio volumen de distribución, peso molecular moderadamente elevado y muy alto porcentaje de fijación a proteínas) hacen poco probable el paso a leche materna de cantidades significativas.

Los efectos secundarios posibles, en combinación con Darunavir, son raros y, en general, de gravedad leve-moderada: diarrea, nauseas, exantema... (Navarro 2016).


See below the information of these related products:

Alternatives

We do not have alternatives for Cobicistat.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Cobicistat in other languages or writings:

Group

Cobicistat belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cobicistat in its composition:

  • Prezcobix™. Contains other elements than Cobicistat in its composition
  • Rezolsta™. Contains other elements than Cobicistat in its composition
  • Symtuza™. Contains other elements than Cobicistat in its composition
  • Tybost™

Pharmacokinetics

Variable Value Unit
Molecular weight 776 daltons
Protein Binding 97 - 98 %
VD 1.4 - 2.1 l/Kg
pKa 14.2 -
Tmax 3.5 hours
T½ 3 - 4 hours

References

  1. SEFH - Sociedad Española de Farmacia Hospitalaria. Procedimientos de farmacia hospitalaria para la gestión del tratamiento con antivirales en la enfermedad por el nuevo coronavirus sars-cov-2 (COVID-19). Recomendaciones de la Sociedad Española de Farmacia Hospitalaria. None 2020 Full text (in our servers)
  2. AEMPS - Gilead. Cobicistat (Tybost). Ficha técnica. 2018 Full text (in our servers)
  3. Navarro J, Curran A. Profile of once-daily darunavir/cobicistat fixed-dose combination for the treatment of HIV/AIDS. HIV AIDS (Auckl). 2016 Oct 31;8:175-182. eCollection 2016. Review. Abstract
  4. EMA - Jansen C. Darunavir-Cobicistat (Rezolsta). Ficha técnica. 2014 Full text (in our servers)

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