Last update March 27, 2015

Clebopride

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Benzamide derivative agent which is similar to Metoclopramide but with higher extrapyramidal side-effects and poorly known pharmacokinetics.

At latest update, relevant published data on excretion into breast milk were not found.

As with Metoclopramide it produces increased secretion of Prolactin.

Until more data on this medication is available, safer alternative drugs are preferred, especially in such critical age periods.

Alternatives

  • Metoclopramide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Clebopride is also known as


Group

Clebopride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Clebopride in its composition:

List of 14 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 374 daltons
Tmax 1 - 2 hours

References

  1. AEMPS. Cleboprida. Ficha técnica. 2014 Full text (in our servers)
  2. Serrano Serrano ME, Alvarez Frejo M, Tabernero García J, Martín Martín S. Síndrome extrapiramidal por cleboprida. \ [An extrapyramidal syndrome due to clebopride]. Aten Primaria. 1999 Abstract Full text (link to original source) Full text (in our servers)
  3. Serrano Serrano ME, Alvarez Frejo M, Tabernero García J, Martín Martín S. [An extrapyramidal syndrome due to clebopride]. Aten Primaria. 1999 Abstract
  4. Cuena Boy R, Maciá Martínez MA. [Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]. Aten Primaria. 1998 Abstract
  5. Cuena Boy R, Maciá Martínez MA. Toxicidad extrapiramidal a metoclopramida y a cleboprida: estudio de las notificaciones voluntarias de reacciones adversas al Sistema Español de Farmacovigilancia. \ [Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]. Aten Primaria. 1998 Abstract Full text (link to original source) Full text (in our servers)
  6. Jiménez-Jiménez FJ, Ortí-Pareja M, Ayuso-Peralta L, Gasalla T, Cabrera-Valdivia F, Vaquero A, Tejeiro J, García-Albea E. Drug-induced parkinsonism in a movement disorders unit: A four-year survey. Parkinsonism Relat Disord. 1996 Abstract
  7. Perez-Lopez FR, Legido A, Sisskin M, Abos MD. Stimulatory effect of clebopride on human prolactin secretion. Fertil Steril. 1980 Abstract

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