Last update Feb. 11, 2025

Cinchocaine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Cincocaine or dibucaine is an amide-type local anesthetic used only for superficial local anesthesia. It is a very potent long-acting anesthetic that has been used in spinal anesthesia. Topical administration in the form of creams and ointments.

At the date of the last update we found no published data on its excretion in breast milk.

Topical anesthetics (well applied dermatological and stomatological preparations) have virtually no systemic absorption. Higher absorption possible if applied on inflamed skin.

After application to a perineal wound, the concentrations reached in serum were very low or undetectable without being able to produce systemic effects. (Harrison 1987)

Do not apply on the breast or, if necessary, apply after a feeding and clean well with water before the next feeding. It has caused severe and fatal intoxications in children after oral ingestion. (Nelsen 2009, Dayan 1996).

Avoid applying creams, gels and other locally applied products containing kerosene (mineral oil) on the nipple so that the infant does not absorb it. (Concin 2008, Noti 2003)
 

Alternatives

  • Lidocaine (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cinchocaine is also known as


Cinchocaine in other languages or writings:

Tradenames

Main tradenames from several countries containing Cinchocaine in its composition:

  • Anestesia Local Braun S/A™. Contains other elements than Cinchocaine in its composition
  • Borraginol-N™. Contains other elements than Cinchocaine in its composition
  • Cincain
  • Decatylen™. Contains other elements than Cinchocaine in its composition
  • Decatylen (Декатилен)™. Contains other elements than Cinchocaine in its composition
  • Decatyleno™. Contains other elements than Cinchocaine in its composition
  • Deliproct™. Contains other elements than Cinchocaine in its composition
  • DoloPosterine N
  • Faktu™. Contains other elements than Cinchocaine in its composition
  • Hemorrocort™. Contains other elements than Cinchocaine in its composition
  • Locaseptil-Neo™. Contains other elements than Cinchocaine in its composition
  • Medi-Keel A™. Contains other elements than Cinchocaine in its composition
  • Nupercainal
  • Nupercaine
  • Orodrops
  • Otaset
  • Otobacid N™. Contains other elements than Cinchocaine in its composition
  • Otogesic™. Contains other elements than Cinchocaine in its composition
  • Procto Venart™. Contains other elements than Cinchocaine in its composition
  • Proctoacid™. Contains other elements than Cinchocaine in its composition
  • Proctol™. Contains other elements than Cinchocaine in its composition
  • Proctomyxin HC™. Contains other elements than Cinchocaine in its composition
  • Proctosedyl™. Contains other elements than Cinchocaine in its composition
  • Proctox-H™. Contains other elements than Cinchocaine in its composition
  • Proctyl™. Contains other elements than Cinchocaine in its composition
  • Proktosedon™. Contains other elements than Cinchocaine in its composition
  • Ratio-Proctosone™. Contains other elements than Cinchocaine in its composition
  • Rectinol™. Contains other elements than Cinchocaine in its composition
  • Ruscus™. Contains other elements than Cinchocaine in its composition
  • Scheriproct™. Contains other elements than Cinchocaine in its composition
  • Spofax™. Contains other elements than Cinchocaine in its composition
  • Supraproct-S™. Contains other elements than Cinchocaine in its composition
  • Ultraproct™. Contains other elements than Cinchocaine in its composition
  • Ultraproct (Ультрапрокт)™. Contains other elements than Cinchocaine in its composition
  • Una A™. Contains other elements than Cinchocaine in its composition
  • Uniroid-HC™. Contains other elements than Cinchocaine in its composition

Pharmacokinetics

Variable Value Unit
Molecular weight 344 daltons
pKa 14.57 -

References

  1. Nelsen J, Holland M, Dougherty M, Bernad J, Stork C, Marraffa J. Severe central nervous system and cardiovascular toxicity in a pediatric patient after ingestion of an over-the-counter local anesthetic. Pediatr Emerg Care. 2009 Oct;25(10):670-3. Abstract
  2. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  3. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  4. Dayan PS, Litovitz TL, Crouch BI, Scalzo AJ, Klein BL. Fatal accidental dibucaine poisoning in children. Ann Emerg Med. 1996 Oct;28(4):442-5. Abstract
  5. Harrison RF, Brennan M. Evaluation of two local anaesthetic sprays for the relief of post-episiotomy pain. Curr Med Res Opin. 1987 Abstract

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