Last update Feb. 19, 2019

Chorionic Gonadotrophin Alpha

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is the synthetic form of the natural human chorionic gonadotropin (hCG) hormone, produced by recombinant DNA technology.
Administration by subcutaneous injection.
Indicated to stimulate ovulation in assisted reproduction techniques.

Since the last update we have not found published data on its excretion in breastmilk.

Its high molecular weight makes it very unlikely it will transfer into milk in significant quantities.

Due to its protein nature it is inactivated in the gastrointestinal tract, not being absorbed, so its oral bioavailability is practically nil, except in premature babies and the immediate neonatal period when there may be greater intestinal permeability.

May cause increased prolactin and galactorrhea (Mendes 2001).

No adverse effects have been recorded in infants.

In infertility treatments, the possible theoretical anovulatory effect of frequent on demand breastfeeding must be taken into account.

See below the information of these related products:


We do not have alternatives for Chorionic Gonadotrophin Alpha.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Chorionic Gonadotrophin Alpha is also known as Choriogonadotropin Alfa.

Chorionic Gonadotrophin Alpha in other languages or writings:


Chorionic Gonadotrophin Alpha belongs to this group or family:


Main tradenames from several countries containing Chorionic Gonadotrophin Alpha in its composition:


Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 25.720 daltons
VD 0.9 l/Kg
29 ± 6 hours


  1. EMA. Coriogonadotropina alfa (Ovitrelle). Ficha técnica. 2017 Full text (in our servers)
  2. EMA. Choriogonadotropin alfa (Ovitrelle). Drug Summary 2017 Full text (in our servers)
  3. Mendes MC, Ferriani RA, Sala MM, Moura MD, Carrara HH, de Sá MF. Effect of transitory hyperprolactinemia on in vitro fertilization of human oocytes. J Reprod Med. 2001 Abstract

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