Last update Jan. 16, 2023

Chlorthalidone, Chlortalidone

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

It is a diuretic used to treat hypertension or edema caused by heart failure, kidney failure, liver cirrhosis, estrogen therapy, and other conditions. Oral administration.

It is excreted in breast milk in an amount that could be significant. (Mulley 1978)

In the past it was used to inhibit lactation. (Emran 1966)

Long-term treatment with diuretic drugs (particularly those Thiazides with long lasting effect and loop-acting drugs) may inhibit lactation. Use a lower dose as possible, especially during the first postnatal month.

Its long half-life and the amount that is excreted in milk make the use of an alternative advisable.

However, the American Academy of Pediatrics considers it a medication generally compatible with breastfeeding. (AAP 2001)

Alternatives

  • Chlorothiazide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Furosemide (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Hydrochlorothiazide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Chlorthalidone, Chlortalidone in other languages or writings:

Group

Chlorthalidone, Chlortalidone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Chlorthalidone, Chlortalidone in its composition:

  • Ablok Plus™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Angipress CD™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Apotelodona™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Atelidona™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Atenigron™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Atenoclor™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Atenolol comp™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Atenorese™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Bemplas™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Betacard Plus™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Bioralin
  • Blokium Diu™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Carmian™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Clordilon
  • Clorpres™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Clortalil
  • Clortanol™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Diube™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Diublok™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Euretico
  • Hidropharm
  • Higroton
  • Higroton Blok™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Higroton-Res™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Higrotona
  • Hiprex (Chile)
  • Hydrosan
  • Hygropax
  • Hygroton
  • Hylaton
  • Igroton
  • Lortal
  • Metorene
  • Prenoretic™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Regroton™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Sinhidron
  • TRI-Normin™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Teneretic™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Tenoretic™. Contains other elements than Chlorthalidone, Chlortalidone in its composition
  • Thalitone

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 65 %
Molecular weight 339 daltons
Protein Binding 75 %
VD 3.9 l/Kg
pKa 8.76 -
Tmax 2 - 6 hours
40 - 50 hours
Theoretical Dose 0.014 - 0.13 mg/Kg/d
Relative Dose 6 (1.6 - 15.4) %
Ped.Relat.Dose 13 %

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Ghanem FA, Movahed A. Use of antihypertensive drugs during pregnancy and lactation. Cardiovasc Ther. 2008 Abstract Full text (link to original source) Full text (in our servers)
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  4. Mulley BA, Parr GD, Pau WK, Rye RM, Mould JJ, Siddle NC. Placental transfer of chlorthalidone and its elimination in maternal milk. Eur J Clin Pharmacol. 1978 May 17;13(2):129-31. Abstract
  5. Emran J. [Inhibition of the lactation by Hygroton]. Mars Med. 1966;103(1):69-70. French. No abstract available. Abstract

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