Chlormadinone Acetate

Synthetic progestin-related drug similar to the progesterone used for treatment of uterine bleeding, dysmenorrhea, infertility and occasionally for prostate problems. It has been used as a birth control medication, as single component or in combination with estrogen (e.g. mestranol + chlormadinone).

At the date of the last update we did not find any published data on its excretion in breast milk.

Other related progestin drugs are excreted into breast milk in clinically non-significant amount ^{(Croxatto 1987, Betrabet 1987, Nilsson 1977)} and no problems have been observed in infants whose mothers were treated with this medication. ^{(Roy 2020, Bahamondes 2013, Dutta 2013, Shaamash 2005, Bjarnadóttir 2001, Díaz 1987)}

No changes in prolactin levels or alterations in milk production or composition have been observed in women treated with chlormadinone ^{(Talwar 1977, Beck 1976, Sammour 1973, González 1970, Howard 1969, Martínez 1967)}, except for a slight decrease in the amount of proteins. ^{(Sammour 1973)}

During lactation progestin-only contraceptives are preferable to those combined with estrogen and, in this case, those with a lower dose of estrogen. ^{(CDC 2016, 2013 y 2010, WHO/OMS 2015, Altshuler 2015, Berens 2015, CLM 2012, Moretti 2000)}

For the first 4-6 weeks postpartum, non-hormonal methods are the first choice, followed by IUDs and progestogen implants. ^{(Berens 2015, Mwalwanda 2013, Rowe 2013, CLM 2012)}

See below the information of these related products:

• Ethinylestradiol + Chlormadinone (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
• Mestranol + Chlormadinone (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)