Chlordiazepoxide

Long-acting benzodiazepine with properties similar to diazepam. Indicated in anxiety and insomnia disorders. Intravenous and intramuscular administration in a single dose or orally three to four times a day. Complete oral bioavailability. ^{(Greenblatt 1978)}

Since the last update we have not found any published data on its excretion in breast milk.

Its pharmacokinetic data (low molecular weight, prolonged elimination time and being highly lipophilic) makes transfer to milk possible in amounts which could be significant, but its high protein binding and high volume of distribution would make it difficult.

Its main metabolite is desmethyldiazepam, with an average elimination time of several days.

In low doses and used in a judicious manner, benzodiazepines are compatible with breastfeeding. ^{(Kelly 2012, Rubin 2004, Iqbal 2002, Hägg 2000, McElhatton 1994, Lee 1993, Kanto 1982)}

It is advisable to choose short acting benzodiazepines given at the lowest effective doses ^{(Rowe 2013)}, specially during the neonatal period and in the case of prematurity since during chronic use it might accumulate in the infant. ^{(Sachs 2013)}

It is advisable to watch for somnolence and adequate feeding behaviour in the lactating infant. Bedsharing is not advisable due to an increased risk of SIDS (Sudden infant death syndrome) and asphyxia in lactating infants of mothers taking this medication. ^{(ABM 2020, UNICEF 2018, 2017, 2014 y 2013, Landa 2012, ABM 2008, UNICEF 2006)}

See below the information of this related product:

• Nordazepam (Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.)