Last update Jan. 16, 2023


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Thiazide diuretic with action and uses similar to hydrochlorothiazide. Indicated in the treatment of hypertension and edema secondary to heart failure. Oral administration once-twice a day.

Milk levels of a mother who took 500 mg of chlorothiazide were undetectable or very low, <1 mg / L.(Werthmann 1972)

Despite some older studies, there is no scientific evidence that diuretics reduce breast milk production. (Anderson 2018, Rowe 2013)

Several medical societies, experts and expert consensus, consider the use of this medication safe or probably safe during breastfeeding (Briggs 2015, Hale 2017 p190). American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding. (AAP 2001)

Long-term treatment with diuretic drugs may compromise the state of hydration of the nursing mother. Must make an adjustment (decrease) of the dose based on the estimated milk production and monitor milk production.

See below the information of this related product:


We do not have alternatives for Χλωροθειαζίδη since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Χλωροθειαζίδη is Chlorothiazide in Greek.

Is written in other languages:

Χλωροθειαζίδη is also known as


Χλωροθειαζίδη belongs to this group or family:


Main tradenames from several countries containing Χλωροθειαζίδη in its composition:


Variable Value Unit
Oral Bioavail. 20 %
Molecular weight 296 daltons
Protein Binding 95 %
VD 0.3 l/Kg
pKa 9.1 -
Tmax 1 hours
0.75 - 2 hours
M/P ratio 0.25 -
Theoretical Dose < 0.15 mg/Kg/d
Relative Dose < 1.8 %
Ped.Relat.Dose < 1.5 %


  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Werthmann MW Jr, Krees SV. Excretion of chlorothiazide in human breast milk. J Pediatr. 1972 Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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