Last update Dec. 30, 2021

Χλωροφαινιραμίνη μηλεϊνική

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

First generation antihistaminic and alchylamine drug, with sedative effect. Its active isomer is Dexchlorfeniramine. Oral dosage every 4-6 hours

Since the last update we have not found published data on its excretion in breast milk.

No problems requiring medical attention have been observed in infants of mothers taking chlorpheniramine. (Ito 1993, Paton 1985)

Likely inhibition of lactation within the first weeks post delivery because anti-prolactin effect (WHO 2002, Messinis 1985)

Short-term and low dose (2 mg one or twice-day) treatment is compatible with breastfeeding.(LactMed)

Follow-up for sedation and feeding ability of the infant. (Butler 2014, WHO 2002)

For long-term treatment an alternative drug should be preferred. (Powell 2007)

Compounds in association with expectorants, corticoids and cough relief medicines are available. Avoid drug associations especially while breastfeeding.

Bed-sharing is not recommended for mothers who are taking this medication. (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).


See below the information of this related product:

  • Dexchlorpheniramine Maleate (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Χλωροφαινιραμίνη μηλεϊνική is Chlorphenamine Maleate in Greek.

Is written in other languages:

Χλωροφαινιραμίνη μηλεϊνική is also known as

Group

Χλωροφαινιραμίνη μηλεϊνική belongs to this group or family:

Tradenames

Main tradenames from several countries containing Χλωροφαινιραμίνη μηλεϊνική in its composition:

  • Acemuk día y noche™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Aliren™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Aller-Chlor
  • Allergy
  • Allergy Relief (United States of America)
  • Allerief
  • Antadex-H
  • Anticatarral ™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Antiflu-Des™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Antihistaminico Llorens colirio
  • Apogrip™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Apomin
  • Aseptobron Unicap™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Bregamin AV™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Bronkotuss Expectorant™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Calgayan™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Calimal
  • Carbamyl™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Cefalex Plus™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Chlo-Amine
  • Chlor-Pro
  • Chlor-Trimeton
  • Chlor-Tripolon
  • Chlorohistol
  • Cloro Alergan
  • Cloro-Trimeton
  • Clorotrimeton
  • Clorprimeton
  • Contac™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Coricidin (Indonesia)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Coricidin (United States of America, Venezuela)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Couldina Instant con Paracetamol™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Couldina Instant con Ácido Acetilsalicílico™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Couldina con Ibuprofeno™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Couldina con Paracetamol™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Couldina con Ácido Acetilsalicílico™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Cronal
  • Desenfriol™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Desenfriol C™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Despec PDC™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Dolo-Cold™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Dristan (India)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Dristan (Canada, Turkey)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Dristan Compuesto™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Dristan Max™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Dristan triple acción™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Duohist DH™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Exxon (India)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Facitor™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Fayrus™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Fienamina™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Frenadol™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Frenadol Complex™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Frenadol PS™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Gelocatil gripe con pseudoefedrina™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Gelocatil gripe forte con fenilefrina™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Grippostad (Czech Republic)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Haymine™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Histafen
  • Humex Rhume™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Istamex
  • Kang Yu Deng Tong (康裕登通)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • N-Zolin (India)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Nastizol (Chile)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Nefacool (India)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Novahistine DH™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Novo-Pheniram
  • Numonyl Jarabe™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Ocuclear (India)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Paidoterin
  • Panadol Antigripal™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Piriton
  • Prodel
  • QDALL AR
  • Quelidrine™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Refrianex Compuesto™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Rino Dexa™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Rinogan™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Rosel™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Scadan
  • Sinutab (Brazil)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Tabcin (Mexico)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Tapsin Antigrippal Polvo Noche™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Tapsin Nocturno™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Teldrin
  • Trimeton
  • Tylex Flu (Mexico)™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Unicarbazan™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • Vincigrip™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition
  • XL-3 VR™. Contains other elements than Χλωροφαινιραμίνη μηλεϊνική in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 - 50 %
Molecular weight 391 daltons
Protein Binding 72 %
VD 6 - 12 l/Kg
pKa 9.2 -
Tmax 2.5 - 6 hours
12 - 25 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  3. UNICEF UK. Caring for your baby at night. A guide for parents. 2018 Full text (link to original source) Full text (in our servers)
  4. UNICEF. Ball H, Blair PS. (For UNICEF UK). Caring for your baby at night. Health professional´s guide. 2017 Full text (link to original source) Full text (in our servers)
  5. UNICEF UK. Statement on co-sleeping following publication of new NICE postnatal guidance. Infosheet. 2014 Full text (link to original source) Full text (in our servers)
  6. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  7. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. None 2013 Full text (link to original source) Full text (in our servers)
  8. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  9. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008 Abstract Full text (link to original source) Full text (in our servers)
  10. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  11. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007 Abstract Full text (link to original source) Full text (in our servers)
  12. del Cuvillo A, Mullol J, Bartra J, Dávila I, Jáuregui I, Montoro J, Sastre J, Valero AL. Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol. 2006;16 Suppl 1:3-12. Review. No abstract available. Abstract Full text (link to original source) Full text (in our servers)
  13. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  14. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  15. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  16. Messinis IE, Souvatzoglou A, Fais N, Lolis D. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985 Apr;8(2):143-6. Abstract
  17. Paton DM, Webster DR. Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985 Nov-Dec;10(6):477-97. Review. Abstract

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