Last update Jan. 11, 2023

Chenodeoxycholic Acid (CDCA)

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a natural bile acid present in human bile. It suppresses the hepatic synthesis and secretion of cholesterol and inhibits the intestinal absorption of cholesterol. It is an epimer of ursodeoxycholic acid. It is used for the treatment of primary biliary cirrhosis and the dissolution of gallstones. Oral administration one to three times a day.

At the date of the last update we did not find any published data on its excretion in breast milk, but since it is an epimer of ursodeoxycholic acid, compatible with breastfeeding, similar pharmacokinetics are to be expected.

It is a bile salt that partially epimerizes to ursodeoxycholic acid that appears in very low levels in the serum (and breast milk) because it is delivered to portal circulation and completely excreted by the liver through the bile duct.

It has been used as a dietary supplement in neonates and children with inborn errors of bile acid synthesis.

Bile salts are found in breast milk in small amounts (Forsyth 1983). Altered bile acid ratios in breast milk have been linked to prolonged jaundice from breastfeeding. (Forsyth 1990)


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Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Chenodeoxycholic Acid (CDCA) is also known as


Chenodeoxycholic Acid (CDCA) in other languages or writings:

Group

Chenodeoxycholic Acid (CDCA) belongs to this group or family:

Tradenames

Main tradenames from several countries containing Chenodeoxycholic Acid (CDCA) in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 393 daltons
pKa 4.6 -

References

  1. Crosignani A, Setchell KD, Invernizzi P, Larghi A, Rodrigues CM, Podda M. Clinical pharmacokinetics of therapeutic bile acids. Clin Pharmacokinet. 1996 May;30(5):333-58. Review. Abstract
  2. Forsyth JS, Donnet L, Ross PE. A study of the relationship between bile salts, bile salt-stimulated lipase, and free fatty acids in breast milk: normal infants and those with breast milk jaundice. J Pediatr Gastroenterol Nutr. 1990 Aug;11(2):205-10. Abstract
  3. Forsyth JS, Ross PE, Bouchier IA. Bile salts in breast milk. Eur J Pediatr. 1983 Apr;140(2):126-7. Abstract

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