Last update Sept. 2, 2021


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Second-generation cephalosporin for oral or parenteral administration in two daily doses.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Kiriazopoulos 2017, Nakamura 1987, Amiraslanova 1985, Voropaeva 1982).
No problems have been observed in infants whose mothers have taken it (Benyamini 2005).

Intravenously administered Cefuroxime salt is not orally absorbed.

Cephalosporins are widely used in the Pediatric practice with a good tolerance (Powell 1991), even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account (Benyamini 2005, Ito 1993).

Expert authors consider the use of this medication safe during breastfeeding (Hale, Lactmed, Briggs 2015, Schaefer 2015, Rowe 2013).


We do not have alternatives for Cefuroxime since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefuroxime is also known as

Cefuroxime in other languages or writings:


Main tradenames from several countries containing Cefuroxime in its composition:


Variable Value Unit
Oral Bioavail. 30 - 50 %
Molecular weight 424 daltons
Protein Binding 35 - 50 %
VD 0,33 l/Kg
pKa 3,15 -
Tmax 0,75 - 3 hours
T1/2 1,1 - 1,5 hours
Theoretical Dose 0,22 mg/Kg/d
Relative Dose 1,3 - 2,6 %
Ped.Relat.Dose 0,2 %

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