Last update May 23, 2025

Ceftizoxime Sodium

Compatible

Safe product and/or breastfeeding is the best option.

Third-generation cephalosporin antibiotic for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Takase 1980, Motomura 1980, Gerding 1982, Matsuda 1984).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

BAlthough rare, the possibility of transient gastroenteritis due to alteration of the intestinal microbiome in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Several medical societies and expert authors consider it safe to use this medication during breastfeeding. (Hale, LactMed, Briggs 2015)

Alternatives

We do not have alternatives for Ceftizoxime Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ceftizoxime Sodium in other languages or writings:

Group

Ceftizoxime Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ceftizoxime Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 5 %
Molecular weight 405 daltons
Protein Binding 30 %
VD 0.35 - 0.4 l/Kg
pKa 3.6 -
Tmax 1 hours
1.7 hours
Theoretical Dose 0.0015 - 0.12 mg/Kg/d
Relative Dose 0.009 - 0.7 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  5. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  6. Cho N, Fukunaga K, Kunii K, Tezuka K, Kobayashi I. [Studies of ceftizoxime in perinatal period]. Jpn J Antibiot. 1988 Abstract
  7. Ito K, Izumi K, Takagi H, Yokoyama Y, Tamaya T, Baba Y, Hayasaki M. [Pharmacokinetic and clinical studies of ceftizoxime in obstetrical and gynecological field (2)]. Jpn J Antibiot. 1988 Abstract
  8. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  9. Gerding DN, Peterson LR. Comparative tissue and extravascular fluid concentrations of ceftizoxime. J Antimicrob Chemother. 1982 Abstract
  10. akase Z, Inoue K, Shirafuji H et al. Clinical and laboratory studies on ceftizoxime (CZX) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 5):863-73. 1980
  11. Motomura R, Kohno M, Mori H, Yamabe T. Basic and clinical studies of ceftizoxime in obstetrics and gynecology. Chemotherapy (Tokyo) 1980;28(Suppl 5):888–99. 1980

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