Last update May 22, 2025

Cefpodoxime Proxetil

Compatible

Safe product and/or breastfeeding is the best option.

Third-generation cephalosporin antibiotic. Oral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant. (FDA 2013, AEMPS 2012)

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Hyperprolactinaemia and galactorrhoea have been reported. (Das 2020, Khurana 2010)

Several medical societies, expert authors and the manufacturer consider this medication safe for use during breastfeeding. (Hale, LatMed, Briggs 2015, AEMPS 2012)

Alternatives

We do not have alternatives for Cefpodoxime Proxetil since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefpodoxime Proxetil in other languages or writings:

Group

Cefpodoxime Proxetil belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 %
Molecular weight 558 daltons
Protein Binding 22 - 40 %
VD 0.5 l/Kg
Tmax 2 - 3 hours
2 - 3 hours
M/P ratio 0.16 -
Theoretical Dose 0.055 mg/Kg/d
Relative Dose 1.6 %
Ped.Relat.Dose 0.55 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Das N, Chadda RK. Hyperprolactinemic Galactorrhea Associated With Cefpodoxime in a Patient With Recurrent Depressive Disorder on Venlafaxine Monotherapy: A Case Report. J Clin Psychopharmacol. 2020 Nov/Dec;40(6):635-636. Abstract
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. FDA. Cefpodoxime. Drug Summary. 2013 Full text (in our servers)
  6. AEMPS. Cefpodoxima. Ficha técnica. 2012 Full text (in our servers)
  7. Khurana V, Gambhir IS. Cefpodoxime-induced hyperprolactinemic galactorrhea. Ann Intern Med. 2010 Abstract
  8. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  9. Saathoff N, Lode H, Neider K, Depperman KM, Borner K, Koeppe P. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist. Antimicrob Agents Chemother. 1992 Abstract
  10. Tremblay D, Dupront A, Ho C, Coussediere D, Lenfant B. Pharmacokinetics of cefpodoxime in young and elderly volunteers after single doses. J Antimicrob Chemother. 1990 Abstract

Total visits

25,587

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM