Last update Oct. 15, 2016

Cefoperazone Sodium

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Third-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Takase 1980, Matsuda 1984 y 85).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefoperazone Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefoperazone Sodium in other languages or writings:

Group

Cefoperazone Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefoperazone Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 668 daltons
Protein Binding 82 - 93 %
VD 0.19 l/Kg
Tmax 1.1 - 2.5 hours
T½ 2 hours
M/P ratio 0.12 -
Theoretical Dose 0.015 - 0.045 mg/Kg/d
Relative Dose 0.09 - 0.27 %
Ped.Relat.Dose 0.06 - 0.1 %

References

  1. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  2. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  3. Matsuda S, Kashiwagura T, Hirayama H. [Passage into the human milk and clinical evaluation of sulbactam/cefoperazone]. Jpn J Antibiot. 1985 Abstract
  4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  5. Takase Z, Shirafuji H, Uchida M. Fundamental and clinical studies of cefoperazone (T-1551) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 6):825-36. 1980

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