Last update May 23, 2025

Cefoperazone Sodium

Compatible

Safe product and/or breastfeeding is the best option.

Third-generation cephalosporin antibiotic for injection or parenteral administration.

Like most cephalosporins for which data are available (Rowe 2013, Fulton 1992), excretion occurs in breast milk in very small amount and it is clinically insignificant. (Matsuda 1985 & 1984. Takase 1980)

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal microbiome in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Several medical societies and expert authors consider it safe to use this medication during breastfeeding. (LactMed)

Alternatives

We do not have alternatives for Cefoperazone Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefoperazone Sodium in other languages or writings:

Group

Cefoperazone Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefoperazone Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 668 daltons
Protein Binding 82 - 93 %
VD 0.19 l/Kg
Tmax 1.1 - 2.5 hours
T½ 2 hours
M/P ratio 0.12 -
Theoretical Dose 0.015 - 0.045 mg/Kg/d
Relative Dose 0.09 - 0.27 %
Ped.Relat.Dose 0.06 - 0.1 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  5. Matsuda S, Kashiwagura T, Hirayama H. [Passage into the human milk and clinical evaluation of sulbactam/cefoperazone]. Jpn J Antibiot. 1985 Abstract
  6. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  7. Takase Z, Shirafuji H, Uchida M. Fundamental and clinical studies of cefoperazone (T-1551) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 6):825-36. 1980

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