Last update May 23, 2025

Cefdinir

Compatible

Safe product and/or breastfeeding is the best option.

Third-generation cephalosporin antibiotic. Oral administration.

At latest update no published data on excretion into breast milk were found.

According to the manufacturer it is not excreted into breast milk. (Abbott 2007)

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view (Rowe 2013, Fulton 1992) without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Red discoloration of stools would appear when combined with iron supplements. (Lancaster 2008)

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal microbiome in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Several medical societies and expert authors consider it safe to use this medication during breastfeeding. (Hale, LactMed, Briggs 2015, Bar 2003)

Alternatives

We do not have alternatives for Cefdinir since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefdinir in other languages or writings:

  • سافدينير (Arabic)
  • Цефдинир (Cyrillic)
  • 头孢地尼 (Chinese)
  • セフジニル (Japanese)
  • (-)-(6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 72-(Z)-oxime; 7-{(2-Amino-1,3-thiazol-4-yl)-2-[(Z)-hydroxyimino]acetamido}-3-vinylcephem-4-carboxylic acid (Chemical name)
  • C14H13N5O5S2 (Molecular formula)
  • J01DD15 (ATC Code/s)

Group

Cefdinir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefdinir in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 16 - 25 %
Molecular weight 395 daltons
Protein Binding 60 - 70 %
VD 0.35 - 2.09 l/Kg
pKa 3.61 -
Tmax 2 - 4 hours
T½ 1.7 ± 0.6 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. Lancaster J, Sylvia LM, Schainker E. Nonbloody, red stools from coadministration of cefdinir and iron-supplemented infant formulas. Pharmacotherapy. 2008 Abstract
  6. Abbott. Omnicef. Drug Summary. 2007 Full text (in our servers)
  7. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  8. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract

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