Last update March 3, 2025

Camphor

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Substance derived from the distillation of the bark of the camphor tree. Today it is synthesized from turpentine. It is used as a local anti-inflammatory for the skin in creams and lotions. There is no evidence of its decongestive or expectorant effect in preparations for inhalation and there is evidence of its toxicity. Topical cutaneous, oral or nasal administration.

At the date of the last update we found no published data on its excretion in breast milk.

Camphor is a very lipophilic substance that is very well absorbed by any route of administration (cutaneous, inhalation, oral...) crossing well the cell membranes. (Zuccarini 2009).

Its pharmacokinetic data make it likely to pass into milk in quantities that could be significant.

Camphor is neurotoxic and hepatotoxic (Bunchorntavakul 2013, Chitturi 2008), even in small doses and by cutaneous topical route, especially in children, causing headache, vomiting, convulsions and coma. (Nchinech 2019, Michiels 2010, Khine 2009, Zuccarini 2009, Guilbert 2007, Manoguerra 2006, Love 2004, Burkhard 1999, Gouin 1996, Theis 1995, Liebelt 1993, Joly 1980)

It should never be administered orally. It is not a suitable product for use during breastfeeding and in any case it should not be applied on the mother's breast as serious intoxications have occurred in children with small quantities ingested or applied in the nostrils.

If used during breastfeeding, to minimize exposure it may be advisable to wait 5 half-lives (T ½ ), about 10 hours after ingestion or application of a dose of camphor before resuming breastfeeding.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Camphor is also known as


Camphor in other languages or writings:

Tradenames

Main tradenames from several countries containing Camphor in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 152 daltons
Protein Binding 61 %
VD 2 - 4 l/Kg
Tmax 1 - 3 hours
1.5 - 3 hours

References

  1. Nchinech N, Elgharbi A, Aglili FZ, Kriouile Y, Cherrah Y, Mdaghri AA, Serragui S. [Traditional camphor misuse: a forgotten danger to children (about 2 cases)]. Pan Afr Med J. 2019 Feb 26;32:89. Abstract Full text (link to original source)
  2. Bunchorntavakul C, Reddy KR. Review article: herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther. 2013 Abstract Full text (link to original source) Full text (in our servers)
  3. Michiels EA, Mazor SS. Toddler with seizures due to ingesting camphor at an Indian celebration. Pediatr Emerg Care. 2010 Aug;26(8):574-5. Abstract
  4. Khine H, Weiss D, Graber N, Hoffman RS, Esteban-Cruciani N, Avner JR. A cluster of children with seizures caused by camphor poisoning. Pediatrics. 2009 Abstract
  5. Zuccarini P. Camphor: risks and benefits of a widely used natural product. Journal of Applied Sciences & Environmental Management, Vol. 13, No. 2, pp. 69-74. 2009 Full text (link to original source) Full text (in our servers)
  6. Chitturi S, Farrell GC. Hepatotoxic slimming aids and other herbal hepatotoxins. J Gastroenterol Hepatol. 2008 Abstract Full text (link to original source) Full text (in our servers)
  7. Guilbert J, Flamant C, Hallalel F, Doummar D, Frata A, Renolleau S. Anti-flatulence treatment and status epilepticus: a case of camphor intoxication. Emerg Med J. 2007 Abstract Full text (link to original source)
  8. Manoguerra AS, Erdman AR, Wax PM, Nelson LS, Caravati EM, Cobaugh DJ, Chyka PA, Olson KR, Booze LL, Woolf AD, Keyes DC, Christianson G, Scharman EJ, Troutman WG; American Association of Poison Control Centers. Camphor Poisoning: an evidence-based practice guideline for out-of-hospital management. Clin Toxicol (Phila). 2006 Abstract Full text (link to original source) Full text (in our servers)
  9. Love JN, Sammon M, Smereck J. Are one or two dangerous? Camphor exposure in toddlers. J Emerg Med. 2004 Abstract
  10. Martin D, Valdez J, Boren J, Mayersohn M. Dermal absorption of camphor, menthol, and methyl salicylate in humans. J Clin Pharmacol. 2004 Abstract
  11. Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol. 1999 Aug;246(8):667-70. Abstract
  12. Gouin S, Patel H. Unusual cause of seizure. Pediatr Emerg Care. 1996 Abstract
  13. Theis JG, Koren G. Camphorated oil: still endangering the lives of Canadian children. CMAJ. 1995 Abstract Full text (link to original source)
  14. Liebelt EL, Shannon MW. Small doses, big problems: a selected review of highly toxic common medications. Pediatr Emerg Care. 1993 Abstract
  15. Joly C, Bouillie C, Hummel M. [Acute poisoning by camphor administered externally in an infant]. Ann Pediatr (Paris). 1980 Abstract

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