Last update Jan. 29, 2017


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Synthetic drug analog to vitamin D3 which is similar to calcitriol.
It is topically used on the treatment of psoriasis.

At latest update relevant published data on excretion into breast milk were not found.

Due to a poor gut absorption, plasma levels were undetectable or very low (AEMPS 2014), so it is unlikely a passage in significant amounts into breastmilk.
In addition, it is a derivative of vitamin D3 with poor effect on calcium metabolism. No significant changes on calcium plasma levels have been observed, whenever compliance with the maximum recommended doses is followed (Murdoch 1992, Bourke 1993 and 1997, Blum 1998).

Therefore, several consensus of experts accept the use of Calcipotriol as safe while breastfeeding (Zip 2002, Leachman 2006, Strober 2009, Barrett 2013, Butler 2014) which can even be applied to the nipple whenever necessary (Barrett 2013 ).
It can be applied for long time periods during breastfeeding provided it would not cover more than 20% of body surface area (Barrett 2013).

It should be avoided application on the nipple of creams, gels and other topical containing-paraffin products (mineral oil) so that the infant would not absorb them (Noti 2003, Concin 2008).
In case of psoriasis of the nipple it should be applied after a feeding at breast followed by a thoroughly cleaning up with water before the next feeding.


We do not have alternatives for Calcipotriol since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Calcipotriol is also known as

Calcipotriol in other languages or writings:


Calcipotriol belongs to this group or family:


Main tradenames from several countries containing Calcipotriol in its composition:


Variable Value Unit
Oral Bioavail. Derm: < 5 %
Molecular weight 413 daltons
Protein Binding 64 %
5 - 6 hours


  1. Koh YP, Tian EA, Oon HH. New changes in pregnancy and lactation labelling: Review of dermatologic drugs. Int J Womens Dermatol. 2019 May 16;5(4):216-226. Abstract Full text (link to original source)
  2. Leo. Calcipotriene (Dovonex). Drug Summary. 2015 Full text (in our servers)
  3. AEMPS. Calcipotriol-Betametasona (Daivobet). Ficha técnica. 2014 Full text (in our servers)
  4. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  5. Barrett ME, Heller MM, Fullerton Stone H, Murase JE. Dermatoses of the breast in lactation. Dermatol Ther. 2013 Abstract
  6. Leo. Calcipotriol & Betamethasone (Dovobet). Product Monograph. 2011 Full text (in our servers)
  7. Strober B, Berger E, Cather J, Cohen D, Crowley JJ, Gordon KB, Gottlieb A, Horn EJ, Kavanaugh AF, Korman NJ, Krueger GG, Leonardi CL, Menter A, Schwartzman S, Sobell JM, Young M. A series of critically challenging case scenarios in moderate to severe psoriasis: a Delphi consensus approach. J Am Acad Dermatol. 2009 Abstract
  8. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  9. AEMPS. Calcipotriol (Daivonex). Ficha técnica. 2007 Full text (in our servers)
  10. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006 Abstract
  11. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  12. Zip C. Common sense dermatological drug suggestions for women who are breast-feeding. Skin Therapy Lett. 2002 Abstract
  13. Blum R, Schwartzel E, Siskin S, Epinette WW. Evaluating the safety of calcipotriene 30 g per day in patients with psoriasis: a parallel group, vehicle-controlled study. J Clin Pharmacol. 1998 Abstract
  14. Bourke JF, Berth-Jones J, Mumford R, Iqbal SJ, Hutchinson PE. High dose topical calcipotriol consistently reduces serum parathyroid hormone levels. Clin Endocrinol (Oxf). 1994 Abstract
  15. Bourke JF, Berth-Jones J, Iqbal SJ, Hutchinson PE. High-dose topical calcipotriol in the treatment of extensive psoriasis vulgaris. Br J Dermatol. 1993 Abstract
  16. Murdoch D, Clissold SP. Calcipotriol. A review of its pharmacological properties and therapeutic use in psoriasis vulgaris. Drugs. 1992 Abstract

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