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A synthetic analogue of vitamin D3, similar to calcitriol. It is applied topically once or twice a day for the treatment of psoriasis.
As of the date of the last update, we found no published data on its excretion in breast milk.
Given its low absorption, plasma levels are undetectable or very low (AEMPS 2018), so it is unlikely that significant amounts will pass into milk.
It is also a derivative of vitamin D3 with little effect on calcium metabolism. No significant alterations in serum calcium levels have been observed, provided the maximum recommended doses of 10,000 IU/day or 20% of body surface area are adhered to. (Gottlieb 2019, Barret 2013)
For all these reasons, there is expert consensus that the use of calcipotriol is safe during breastfeeding (Yaghi 2024, Koh 2019, Gottlieb 2019, Butler 2014, Barret 2013, Leachman 2006) and that it may even be applied to the nipple if necessary. (Barrett 2013)
It is recommended to clean the breast before breastfeeding to prevent transfer via skin-to-skin contact, and to prefer cream or gel formulations over ointments to avoid oral absorption of paraffin (mineral oil).(Noti 2003, Concin 2008).