Last update Feb. 16, 2023
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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C6492H10060N1724O2028S42 is Benralizumab in Molecular formula.
Is written in other languages:C6492H10060N1724O2028S42 belongs to these groups or families:
Main tradenames from several countries containing C6492H10060N1724O2028S42 in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | ≈ 0 | % |
Molecular weight | 146.054 | daltons |
VD | 0.05 - 0.1 | l/Kg |
T½ | 360 - 432 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
It is a fully humanized anti-IL-5 IgG1 kappa monoclonal antibody used in conjunction with other therapies to treat severe eosinophilic asthma. It should not be used to treat an acute asthma attack. Subcutaneous administration once every 4 weeks.
Since the last update we have not found published data on its excretion in breastmilk.
It´s very high molecular weight (> 100,000 Da) makes it very unlikely to pass into breast milk in a significant quantity, since molecules of more than 500 - 1,000 Da do not pass into breast milk. (Hale, Almas 2016, Anderson 2016)
Null or negligible passage into breast milk of similar monoclonal antibodies, such as adalimumab, belimumab, certolizumab, golimumab, infliximab, ipilimumab, natalizumab, omalizumab, rituximab, tocilizumab and ustekinumab has been confirmed. (Bar-Gil 2021, LaHue 2020, Ciplea 2020, Ciplea 2020, Saito 2020, 2019 and 2018, Krysko 2019, Whittam 2019, Klenske 2019, Matro 2018, Anderson 2018, Bragnes 2017, Witzel 2014, Ross 2014, Fritzsche 2012)
Due to its protein nature, it is inactivated in the gastrointestinal tract without being absorbed (practically nil oral bioavailability) and this hinders or prevents its passage into the infant´s plasma from ingested breast milk (Lactmed, Rademaker 2018, Bragnes 2017, Götestam 2016 , Witzel 2014, Butler 2014, Mervic 2014), except for premature infants and during the immediate neonatal period when there might be a greater intestinal permeability. (Sammaritano 2020)
No problems have been detected in infants whose mothers received other similar monoclonal antibodies such as belimumab, bevacizumab, infliximab, omalizumab, rituximab, tocilizumab, or ustekinumab. (Bar-Gil 2021, LaHue 2020, Saito 2020, 2019 and 2018, Klenske 2019, Mugheddu 2019, Krysko 2019, Matro 2018, Bragnes 2017, Hyrich 2014, Danve 2014)
Expert authors consider that the use of this (Middleton 2020) or other monoclonal antibodies during breastfeeding is safe or very likely to be safe. (Middleton 2020, Whittam 2019, Matro 2018, Anderson 2018 and 2016, Witzel 2014, Pistilli 2013)