Last update June 4, 2016
Very Low Risk
Pharmacokinetic data (moderately high molecular weight and high protein binding capacity) explain its nil or negligible amount observed in breast milk (McNamara, 2004), such that a breastfed infant would receive a maximum of 35 micrograms per day of Itraconazole, amount which is a hundred times lower than the pediatric dose of 5 mg / kg / day currently recommended (Janssen Cazzaniga 2014 and 1996)
Both, low oral bioavailability and alkaline pH hinder its absorption from ingested milk.
It is used to treat fungal infections in children, including premature babies, with a good tolerance.
Itraconazole significantly increases plasma concentrations of Domperidone, which must be taken into account in case of simultaneous administration of both drugs.
We do not have alternatives for C35H38Cl2N8O4 since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.