Last update Oct. 20, 2023

C32H43N5O5,CH4O3S

Incompatible

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Commentary.

Dihydroergocryptine mesylate is a derivative of ergot, a component of codergocrine mesylate, and has similar actions. It has been used in the treatment of migraine, parkinsonism, senile dementia, cerebrovascular and peripheral vascular disorders, prolactinomas and to inhibit lactation. Oral administration.

At the time of the last update, we found no published data on its excretion in breast milk.

Like all ergot derivatives, it is a dopaminergic agonist and therefore reduces prolactin secretion and may suppress lactation. (Mirkou 2012, Nappi 1993)


See below the information of these related products:

  • Co-dergocrine Mesilate, codergocrine (Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Commentary.)
  • Ergot Fungus (Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Commentary.)

Alternatives

We do not have alternatives for C32H43N5O5,CH4O3S.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

C32H43N5O5,CH4O3S is Dihydroergocryptyne Mesilate in Molecular formula.

Is written in other languages:

Group

C32H43N5O5,CH4O3S belongs to this group or family:

Tradenames

Main tradenames from several countries containing C32H43N5O5,CH4O3S in its composition:

List of 6 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja-los %
Molecular weight 674 daltons
Tmax 3 hours
T½ 25 hours

References

  1. [No authors listed] Do not use drugs to prevent onset of lactation. Relieve the discomfort and wait. Prescrire Int. 2013 Abstract
  2. Mirkou A, Suchovsky D, Gouraud A, Gillet A, Bernard N, Descotes J, Vial T. [Prescription of ergot derivatives for lactation inhibition in France: Current practices]. J Gynecol Obstet Biol Reprod (Paris). 2012 Apr;41(2):167-73. Abstract Full text (link to original source)
  3. Ronca F, Guazzelli M, Salvadori P, Palumbo R, Neuteboom B, Ambrosoli L, Poli A, Girardello R, Lowenthal DT. Pharmacokinetic and Metabolism Study in Healthy Volunteers After Administration of Single Oral Dose of (3)H-alpha-Dihydroergocryptine Mesylate. Am J Ther. 1996 Aug;3(8):553-562. Abstract
  4. Nappi C, Colace G, Di Carlo C, Affinito P, Ruotolo C, Montemagno R, Farace MJ, Mailland F, Di Renzo GF. Effect of dihydroergocryptine on serum prolactin levels and milk secretion in puerperal women. Gynecol Endocrinol. 1993 Jun;7(2):129-33. Abstract

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