Last update Oct. 15, 2016

C16H16N3NaO7S2

Compatible

Safe substance and/or breastfeeding is the best option.

Second-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (references from Geddes 1977 to Zhang 1997).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding

Alternatives

We do not have alternatives for C16H16N3NaO7S2 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

C16H16N3NaO7S2 is Cefoxitin Sodium in Molecular formula.

Is written in other languages:

Group

C16H16N3NaO7S2 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C16H16N3NaO7S2 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 449 daltons
Protein Binding 70 %
VD 0.11 l/Kg
Tmax 0.75 - 1 hours
T½ 0.3 - 0.5 ( im ) hours
Theoretical Dose 0.1 - 0.2 mg/Kg/d
Relative Dose 0.6 - 1.2 %
Ped.Relat.Dose 0.06 - 0.1 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Zhang Y, Zhang Q, Xu Z. [Tissue and body fluid distribution of antibacterial agents in pregnant and lactating women]. Zhonghua Fu Chan Ke Za Zhi. 1997 Abstract
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Roex AJ, van Loenen AC, Puyenbroek JI, Arts NF. Secretion of cefoxitin in breast milk following short-term prophylactic administration in caesarean section. Eur J Obstet Gynecol Reprod Biol. 1987 Abstract
  5. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  6. Dresse A, Lambotte R, Dubois M, Delapierre D, Kramp R. Transmammary passage of cefoxitin: additional results. J Clin Pharmacol. 1983 Abstract
  7. Dubois M, Delapierre D, Chanteux L, Demonty J, Lambotte R, Kramp R, Dresse A. A study of the transplacental transfer and the mammary excretion of cefoxitin in humans. J Clin Pharmacol. 1981 Abstract
  8. Brogden RN, Heel RC, Speight TM, Avery GS. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs 1979;17:1–37 1979
  9. Geddes AM, McGhie D, Ball AP, Gould I. Studies with cefuroxime and cefoxitin. Scand J Infect Dis Suppl. 1978 Abstract
  10. Mashimo K, Mihashi S, Fukaya I, Okubo B, Ohgob M, Saito A. New drug symposium IV. Cefoxitin. Chemotherapy (Tokyo) 1978;26:114–9. 1978
  11. Takase Z, Shirafuji H, Uchida M. Clinical and laboratory studies on cefoxitin in the field of obstetrics and gynecology. Chemotherapy (Tokyo) 1978;26(Suppl 1):502–5. 1978
  12. Geddes AM, Schnurr LP, Ball AP, McGhie D, Brookes GR, Wise R, Andrews J. Cefoxitin: a hospital study. Br Med J. 1977 Abstract Full text (link to original source) Full text (in our servers)

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