Last update Jan. 15, 2020

C13 H20 N2 O2

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

An anesthetic and aminobenzoic acid ester. Administered locally by subcutaneous or intramuscular infiltration (not absorbed by contact with skin or mucous membranes: AEMPS 2007).
Used in skin sutures, dental procedures and for peripheral and spinal block. It is also used to prolong the effect and reduce the pain of the intramuscular administration of penicillin.

Since the last update we have not found published data on its excretion in breastmilk.

It is rapidly hydrolyzed by intestinal and hepatic esters (Inoue 1980) to inactive metabolites (AEMPS 2007, Hospira 2007). Its rapid elimination (half-life of less than 8 minutes: AEMPS 2007, Hospira 2007, Seifen 1979) makes transfer to blood in significant amounts unlikely, so excretion in breastmilk is very unlikely.

Topical anesthetics (well applied ophthalmological, dermatological and stomatological preparations, as creams, subcutaneous injection for infiltration or spinal anesthesia) have virtually no systemic absorption.
Procaine, applied ophthalmologically, poses no risks during breastfeeding.

As there is less published information than for other drugs in the same group, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.

List of essential medicines WHO: Penicillin-Procaine is compatible with breastfeeding (WHO 2002).


  • Articaine Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Benzocaine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Bupivacaine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Lidocaine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ropivacaine Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C13 H20 N2 O2 is Procaine Hydrochloride in Molecular formula.

Is written in other languages:

C13 H20 N2 O2 is also known as


Main tradenames from several countries containing C13 H20 N2 O2 in its composition:


Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 273 daltons
Protein Binding 6 %
pKa 8.05 -
0.13 hours


  1. AEMPS - Serra. Procaína. Ficha técnica. 2007 Full text (in our servers)
  2. Hospira. Procaine (Novocain). Drug Summary. 2007 Full text (in our servers)
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  4. Inoue M, Morikawa M, Tsuboi M, Ito Y, Sugiura M. Comparative study of human intestinal and hepatic esterases as related to enzymatic properties and hydrolizing activity for ester-type drugs. Jpn J Pharmacol. 1980 Aug;30(4):529-35. Abstract
  5. Seifen AB, Ferrari AA, Seifen EE, Thompson DS, Chapman J. Pharmacokinetics of intravenous procaine infusion in humans. Anesth Analg. 1979 Sep-Oct;58(5):382-6. Abstract

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