Last update May 20, 2024

C02CA04

Compatible

Safe substance and/or breastfeeding is the best option.

It is an alpha-1-adrenergic blocking agent that is used for treatment of arterial hypertension and of obstructive symptoms resulting from benign prostatic hypertrophy. Oral administration once a day.

Its pharmacokinetic data, -moderately elevated molecular weight, high percentage of plasma protein binding and high volume of distribution (Pfizer 2017, Kirsten 1998, Elliot 1987)-, probably explain the negligible excretion observed in milk. (Pfizer 2017, Versmissen 2016, Jensen 2013 y 2014)

Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug may be used (Anderson 2018), especially during the neonatal period and/or in case of premature infants.

Alternatives

  • Methyldopa (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

C02CA04 is Doxazosin Mesylate in ATC Code/s.

Is written in other languages:

Groups

C02CA04 belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 65 - 68 %
Molecular weight 548 daltons
Protein Binding 98 - 99 %
VD 1.3 l/Kg
pKa 7.2 -
Tmax 2 (retard: 8 - 9) hours
T½ 19 - 22 hours
M/P ratio 0.1 -
Theoretical Dose 0.0004 - 0.0006 mg/Kg/d
Relative Dose 0.6 - 0.9 %

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. PhI (Pharmascience Inc). Doxazosin. Drug Summary. 2017 Full text (in our servers)
  3. Pfizer. Doxazosina. Ficha técnica. 2017 Full text (in our servers)
  4. Versmissen J, Koch BC, Roofthooft DW, Ten Bosch-Dijksman W, van den Meiracker AH, Hanff LM, Visser W. Doxazosin treatment of phaeochromocytoma during pregnancy: placental transfer and disposition in breast milk. Br J Clin Pharmacol. 2016 Abstract
  5. (Jensen BP, Dalrymple JM, Begg EJ) Corrigendum: Transfer of doxazosin into breast milk. J Hum Lact. 2013 J Hum Lact. 2014 Abstract
  6. Jensen BP, Dalrymple JM, Begg EJ. Transfer of doxazosin into breast milk. J Hum Lact. 2013 Abstract
  7. Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998 Abstract
  8. Elliott HL, Meredith PA, Reid JL. Pharmacokinetic overview of doxazosin. Am J Cardiol. 1987 Abstract

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