Last update Sept. 7, 2022
Glyceryl nitrate or trinitrate or nitroglycerin is a vasodilator used to treat cardiac disorders like ischemia and mainly anal fissures. It is also used during pregnancy as a tocolytic drug in cases of threatened preterm labor and eclampsia (Kashanian 2014, Conde 2013). It is administered intravenously, orally, sublingually, on skin patches, ointment ...
Since the last update we have not found published data on its excretion in breastmilk.
Because of a high volume of distribution and very fast metabolism (Tmax and T1/2 of a few minutes) it is highly unlikely the passage of significant amounts to the breast milk (Kearney 2018), especially when applied topically. This explains why it has not been observed any troubles in 40 infants whose mothers with anal fissures were treated with nitroglycerin ointment application even for periods of 12 months. Mothers have complained of headaches that commonly occur with the use of various vasodilators drugs. (Taylor 2008)
The amount of nitrate / nitrite in this type of vasodilator drugs is of few milligrams, therefore, toxicity associated to nitrates such as methemoglobinemia in breastfed infants from treated mothers has not been reported (The dose of nitrite is Rectogesic 1.5 mg / 12 hours).
It has been used to treat heart disorders in babies and children; even to treat anal fissures in children under 1 year, and noteworthy, in ischemic issues on premature infants, without side effects. (Samiee 2014, Mosalli 2013, Vasquez 2003, Kenny 2001, Wong 1992)
Although it has been used topically to treat Raynaud's phenomenon of the nipple (O'Sullivan 2011), nitroglycerin should not be used topically on the nipples during breastfeeding to prevent it from being taken by the infant.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM