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Bexarotene is a retinoid X receptor agonist used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to prior systemic therapy. Oral administration as a single daily dose.
At the time of the last update, we found no published data on its excretion in breast milk.
Its high binding to plasma proteins makes its passage into breast milk unlikely.
It is known from pharmacokinetics that after 3 elimination half-lives (T½) 87.5% of the drug is eliminated from the body; after 4 T½ 94%, after 5 T½ 96.9%, after 6 T½ 98.4% and after 7 T½ 99%. After 7 T½ the plasma concentrations of drug in the body are negligible. In general, a period of at least five half-lives can be considered a safe waiting period to resume breastfeeding. (Anderson 2016)
Taking the published T½ of this drug (7 hours) as a reference, these 5 T½ would correspond to 35 hours. Due to significant adverse effects (FDA 2015, EMA 2006), it would be advisable to wait 7 T½ which would correspond to 2 days. In the meantime, express and discard breast milk regularly. Since administration is daily, these waiting times make it impossible in practice to continue breastfeeding.
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