Last update Sept. 4, 2022
Very Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Benzhydramine, Diphenhydramine Citrate is also known as Diphenhydramine. Here it is a list of alternative known names::
Benzhydramine, Diphenhydramine Citrate in other languages or writings:
Benzhydramine, Diphenhydramine Citrate belongs to these groups or families:
Main tradenames from several countries containing Benzhydramine, Diphenhydramine Citrate in its composition:
|Oral Bioavail.||40 - 60||%|
|Protein Binding||78 - 85||%|
|VD||3.3 - 6.8||l/Kg|
|Tmax||2 - 3||hours|
|T½||2.4 - 9.3||hours|
|Theoretical Dose||< 0.015||mg/Kg/d|
|Relative Dose||0.45 - 1.2||%|
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
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It is a first generation antihistamine drug (Ethanolamine) with a strong sedative effect. Used in allergic conditions and in motion sickness. Oral administration 3 to 4 times a day
Its large volume of distribution possibly explains the negligible passage into breast milk observed. (Rindi 1951)
No problems have been observed in infants whose mothers took it for a long time (Kaya 2014), except for an isolated case of sedation. (Ito 1993)
The absorption from ingested mother's milk to the infant's plasma is hampered by a low oral bioavailability.
Neither a decrease of milk production nor alteration of Prolactin release have been shown with the use of this drug. (Butler 2014)
For both, the mother and the infant is safer the use of antihistamine medication with higher safety levels without sedative effect (Butler 2014), especially when the child is a premature or younger than 1 month old.
Expert authors consider the use of this medication possibly safe during lactation. (Hale, LactMed, Briggs 2015, Schaefer 2015, Rowe 2013, Nice 2000)
When used while breastfeeding do it with the lower dose as possible and avoid a long-term use.
Check up for feeding difficulty and somnolence in the infant. Bed-sharing with the infant is not recommended for parents who are on this medication. (UNICEF 2018, 2017, 2014, 2013 y 2006, Landa 2012, ABM 2008)
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