Last update Jan. 19, 2023

Bendroflumethiazide

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

It is a thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It is used for hypertension, edema, associated with heart failure, and kidney or liver disorders. It has been used for suppression of the onset of lactation (De Gezelle 1979). Oral administration once a day.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its pharmacokinetic data (very high percentage of protein binding, moderately high molecular weight and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Long-term treatment with diuretic drugs (particularly those Thiazides with long lasting effect and loop-acting drugs) may inhibit lactation. Use a lower dose as possible, especially during the first postnatal month.

Expert authors consider the use of Bendroflumethiazide to be safe during breastfeeding. (Kearney 2018)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Bendroflumethiazide is also known as


Bendroflumethiazide in other languages or writings:

Group

Bendroflumethiazide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Bendroflumethiazide in its composition:

  • Aprinox
  • Bendroza™. Contains other elements than Bendroflumethiazide in its composition
  • Centyl K™. Contains other elements than Bendroflumethiazide in its composition
  • Centyl med Kaliumklorid™. Contains other elements than Bendroflumethiazide in its composition
  • Corgaretic™. Contains other elements than Bendroflumethiazide in its composition
  • Diserim™. Contains other elements than Bendroflumethiazide in its composition
  • Naturetin
  • Neo-Naclex
  • Salures
  • Sumal™. Contains other elements than Bendroflumethiazide in its composition
  • Tensionorme™. Contains other elements than Bendroflumethiazide in its composition
  • Tensoflux™. Contains other elements than Bendroflumethiazide in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 421 daltons
Protein Binding 96 %
VD 1.48 l/Kg
pKa 9.04 -
Tmax 2 hours
3 - 4 hours

References

  1. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)
  2. De Gezelle H, Dhont M, Thiery M, Parewyck W. Puerperal lactation suppression and prolactin. Acta Obstet Gynecol Scand. 1979;58(5):469-72. Abstract

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