Last update July 22, 2022

Beclomethasone, Beclometasone Dipropionate

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is a potent glucocorticoid used inhaled for asthma, nasally for rhinitis and polyps, orally for inflammatory bowel disease, and applied topically on various skin disorders.

At latest update no relevant data on this subject were found in connection with breastfeeding.

Its pharmacokinetic characteristics (low systemic absorption, moderately elevated molecular weight, high plasma protein binding and large volume of distribution), make it highly unlikely that significant quantities will pass into breast milk.

Its low oral bioavailability protects the infant from intestinal absorption.

Only long-term treatment with high doses of inhaled corticosteroids can affect pituitary-adrenal function and growth. (Allen 2020)

Another similar inhaled corticosteroid (Budesonide) is excreted in breast milk in negligible amounts.

Several medical societies and expert authors consider topical, systemic or inhaled steroid medication to be safe or probably compatible with breastfeeding (Hale, LactMed, Middleton 2020, Briggs 2015, Schaefer 2015, Amir 2011, National Asthma 2004, Nice 2004, Ellsworth 1994). WHO Model List of Essential Drugs 2002 rates it as compatible with breastfeeding. (WHO 2002)

TOPICAL USE:

Whenever a treatment for nipple eczema or dermatitis is required, the lowest potency steroid compound should be used. It should be applied right after the feed to make sure it has disappeared before the next nursing. Otherwise, wipe cream out with a clean gauze. Do not continuously use for longer than a week. Reportedly, a case of mineral-steroid toxicity has occurred due to continuous use of cream on the nipple. (De Stefano 1983)

Creams, gels or similar products that contain paraffin or mineral oil should not be used on the nipple to avoid absorption by the infant.(Concin 2008, Noti 2003)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Beclomethasone, Beclometasone Dipropionate in other languages or writings:

Tradenames

Main tradenames from several countries containing Beclomethasone, Beclometasone Dipropionate in its composition:

  • Aldecin
  • Becloasma
  • Becloenema
  • Becloforte
  • Beclosona
  • Beclovent
  • Beconase
  • Becotide
  • Butoso
  • Clipper
  • Combair™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Dereme
  • Formodual™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Fostair™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Foster™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Fostex™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Innovair™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Inuvair™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Inuxair™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Menaderm Clio™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Menaderm Otologico™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Menaderm simple
  • Qvar
  • Recto-Menaderm
  • Trimbow™. Contains other elements than Beclomethasone, Beclometasone Dipropionate in its composition
  • Vanceril

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 41 - 43 %
Molecular weight 521 daltons
Protein Binding 94 %
VD 0.3; metab: 6.1 l/Kg
pKa 13.85 -
Tmax 0.2 - 0.5 hours
5.7 - 8.8 hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on March 17, 2022 Full text (link to original source)
  2. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  3. Allen DB. Inhaled Corticosteroids and Endocrine Effects in Childhood. Endocrinol Metab Clin North Am. 2020 Dec;49(4):651-665. Abstract
  4. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  7. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  8. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  9. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  10. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  11. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  12. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  13. Ellsworth A. Pharmacotherapy of asthma while breastfeeding. J Hum Lact. 1994 Abstract
  14. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983 Abstract

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