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Apremilast is a non-steroidal drug, phosphodiesterase type 4 (PDE-4) inhibitor, used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. Oral administration in two daily doses. (Martindale)
Since the last update we have not found published data on its excretion in breastmilk.
Its low binding to plasma proteins and high pKa facilitates its excretion in breast milk, but its moderately high molecular weight and very large volume of distribution make it difficult.
The most common adverse effects are respiratory infections, diarrhoea, nausea, and headache. (Amgen 2020, EMA 2019)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives may be preferable (Puchner 2019, Rademaker 2018), especially during the neonatal period and in the event of prematurity.