Last update Aug. 9, 2022

Apomorphine Hydrochloride

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a morphine derivative structurally similar to dopamine that is used in the treatment of motor fluctuations in Parkinson's disease and erectile dysfunction. The use of apomorphine to induce vomiting in poisoning is ruled out. Subcutaneous or sublingual administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding, very wide volume of distribution and short half-life) make it highly unlikely that significant quantities will pass into breast milk.

Its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Likely side effects are nausea and vomiting.


We do not have alternatives for Apomorphine Hydrochloride.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Apomorphine Hydrochloride in other languages or writings:


Main tradenames from several countries containing Apomorphine Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 17 %
Molecular weight 313 daltons
Protein Binding 99.9 %
VD 3.1. / Subling: 51.9 l/Kg
pKa 9.26 -
Tmax 0.2 - 1 hours
0.8 - 1.7 hours


  1. Sunovion. Apomorphine. Drug Summary. 2020 Full text (in our servers)
  2. Ever. Apomorfina. Ficha técnica. 2020 Full text (in our servers)

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