Last update Jan. 4, 2022

Anti-D (Rh0) immunoglobulin


Safe substance and/or breastfeeding is the best option.

It is a human immunoglobulin rich in IgG antibodies against the erythrocyte antigen Rho (D). Intramuscular administration.

Since the last update we have not found any published data on its excretion in breast milk.

Its very high molecular weight make it highly unlikely that significant quantities will pass into breast milk. Administration of standard immunoglobulin does not significantly alter the levels of immunoglobulins (IgG or IgM) in colostrum or breast milk. (Palmeira 2009)

No problems have been observed in infants whose mothers are treated with Rho(D) immune globulin. (Hale, LactMed)

Expert authors consider the use of this medication safe during breastfeeding. (Hale, LactMed, Lawrence 2016, Schaefer 2015)

List of WHO essential medicines: compatible with breastfeeding. (WHO / UNICEF 2002)

See below the information of this related product:


We do not have alternatives for Anti-D (Rh0) immunoglobulin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Anti-D (Rh0) immunoglobulin is also known as

Anti-D (Rh0) immunoglobulin in other languages or writings:


Anti-D (Rh0) immunoglobulin belongs to this group or family:


Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 185.000 daltons
Tmax 72 hours
576 hours


  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from Consulted on April 10, 2024 Full text (link to original source)
  3. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  4. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  5. Palmeira P, Costa-Carvalho BT, Arslanian C, Pontes GN, Nagao AT, Carneiro-Sampaio MM. Transfer of antibodies across the placenta and in breast milk from mothers on intravenous immunoglobulin. Pediatr Allergy Immunol. 2009 Sep;20(6):528-35. Abstract
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)

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