Last update Dec. 25, 2022

Amikacin

Compatible

Safe product and/or breastfeeding is the best option.

Es un antibacteriano aminoglucósido semisintético derivado de la kanamicina. Se usa de manera similar a la gentamicina en el tratamiento de infecciones graves por bacterias gramnegativas y otras grampositivas. Administración intramuscular o intravenosa cada 8 a 12 horas.

Se excreta en leche materna en cantidad no detectable o clínicamente no significativa, muy inferior a la dosis utilizada en recién nacidos y lactantes. (Matsuda 1984 y 1974, Yuasa 1974)

Like other aminoglycosides, its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Authorized use in newborns and infants

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Arbex 2010)

Several medical societies and expert authors consider the use of this medication to be safe during breastfeeding. (Hale, LactMed, Briggs 2015, Schaefer 2015,  Baquero 2015, Chin 2001)

Alternatives

We do not have alternatives for Amikacin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Amikacin is also known as


Amikacin in other languages or writings:

Groups

Amikacin belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Amikacin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 586 daltons
Protein Binding < 10 %
VD 0.34 l/Kg
pKa 12.1 -
Tmax 1 - 2 hours
T½ 2 - 3 hours
Theoretical Dose 0 - 0.225 mg/Kg/d
Relative Dose 0 - %
Ped.Relat.Dose 0 - 1.5 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  4. Baquero-Artigao F, Mellado Peña MJ, del Rosal Rabes T, Noguera Julián A, Goncé Mellgren A, de la Calle Fernández-Miranda M, Navarro Gómez ML; Working Group on gestational, congenital, and postnatal tuberculosis, Spanish Society of Pediatric Infectious Diseases (PFIC). Guía de la Sociedad Española de Infectología Pediátrica sobre tuberculosis en la embarazada y el recién nacido (ii): profilaxis y tratamiento. [Spanish Society for Pediatric Infectious Diseases guidelines on tuberculosis in pregnant women and neonates (ii): Prophylaxis and treatment]. An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Arbex MA, Varella Mde C, Siqueira HR, Mello FA. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. J Bras Pneumol. 2010 Sep-Oct;36(5):641-56. Abstract Full text (link to original source) Full text (in our servers)
  7. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  8. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  9. Matsuda S, Mori S, Tanno M, Kashiwagura T. [Evaluation of amikacin in obstetric and gynecological fields (author's transl)]. Jpn J Antibiot. 1974 Abstract
  10. Yuasa M. [Evaluation of amikacin in gynecological and obstetric field (author's transl)]. Jpn J Antibiot. 1974 Abstract

Total visits

103,139

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM