Last update Feb. 12, 2025

Almasilate

Compatible

Safe product and/or breastfeeding is the best option.

A compound based on a hydrated Aluminum and Magnesium silicate mixture. It is an antacid with general properties similar to those of aluminum hydroxide and magnesium carbonate. Oral administration.

Aluminum and magnesium from antacids are not concentrated in breast milk. (Mahadevan 2006, Richter 2005)

The average natural concentration of magnesium in milk is 31 mg/L (15 to 64 mg/L) and is little affected by magnesium administration.(Cruikshank 1982, Dórea 2000, Nagy 1994, Feeley 1983)

Following the intake of aluminum-containing antacids plasma aluminum values rise from basal 7 μg/L to 55 μg/L within half an hour to fall back to their previous value 3 hours later.

Although trace amounts of aluminum may be found in milk, it has no adverse effects on the infant. Breast milk contains an average of 49 μg/L aluminum, much lower than the 180-700 μg/L in artificial formulas. (Burrell 2010, Simmer 1990)

Its low oral bioavailability means that the passage to infant plasma from ingested breast milk is scarce, except in premature infants and immediate neonatal period, in which there may be greater intestinal absorption.

The manufacturer and expert authors consider its use compatible with breastfeeding. (Hale, Rotapharm 2008, Mahadevan 2006, Richter 2005, Broussard 1998)

Avoid chronic or excessive use. List of essential medicines WHO 2002: aluminum and magnesium hydroxides compatible with breastfeeding.(WHO 2002)


See below the information of this related product:

Alternatives

We do not have alternatives for Almasilate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Almasilate is also known as


Almasilate in other languages or writings:

Group

Almasilate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Almasilate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Al: < 1 %
Molecular weight 253 daltons
Protein Binding Al: 94; Mg: 33 %
VD Mg: 0.25 - 0.44 l/Kg

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Burrell SA, Exley C. There is (still) too much aluminium in infant formulas. BMC Pediatr. 2010 Abstract Full text (link to original source) Full text (in our servers)
  3. Rottapharm. Almasilato. Ficha técnica. 2008 Full text (in our servers)
  4. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  5. Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005 Nov 1;22(9):749-57. Review. Abstract Full text (in our servers)
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  7. Dórea JG. Magnesium in human milk. J Am Coll Nutr. 2000 Apr;19(2):210-9. Review. Abstract
  8. Broussard CN, Richter JE. Treating gastro-oesophageal reflux disease during pregnancy and lactation: what are the safest therapy options? Drug Saf. 1998 Oct;19(4):325-37. Review. Abstract
  9. Nagy E, Jobst K. The kinetics of aluminium-containing antacid absorption in man. Eur J Clin Chem Clin Biochem. 1994 Abstract
  10. Simmer K, Fudge A, Teubner J, James SL. Aluminum concentrations in infant formulae. J Paediatr Child Health. 1990 Abstract
  11. Feeley RM, Eitenmiller RR, Jones JB Jr, Barnhart H. Calcium, phosphorus, and magnesium contents of human milk during early lactation. J Pediatr Gastroenterol Nutr. 1983 May;2(2):262-7. Abstract
  12. Cruikshank DP, Varner MW, Pitkin RM. Breast milk magnesium and calcium concentrations following magnesium sulfate treatment. Am J Obstet Gynecol. 1982 Jul 15;143(6):685-8. No abstract available. Abstract

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