Last update Jan. 24, 2017

Alfuzosin Hydrochloride

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Alpha-1 adrenergic blocker that is used on benign prostatic hypertrophy and other problems like voiding difficulty and obstruction including those caused by lithiasis.

At latest update relevant published data on its excretion into breast milk were not found.

Because of a high protein-binding capacity it is unlikely an excretion into breastmilk in significant amounts.

Use not indicated on women. Several studies have reported usefulness for the removal of urinary stones. There is no evidence of efficacy in the prevention of post-traumatic urinary retention.

Since it may cause hypotension in the infant, until more data on this drug is available, a safer and known alternative may be preferable, especially in cases of nursing infants younger than one month of age and premature babies.

Alternatives

  • Oxybutynin (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Tamsulosin (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Alfuzosin Hydrochloride in other languages or writings:

Group

Alfuzosin Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Alfuzosin Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 64 %
Molecular weight 426 daltons
Protein Binding 90 %
VD 2.5 l/Kg
Tmax 3 - 5 hours
3 - 8 hours

References

  1. AEMPS. Alfuzosina. Ficha técnica. 2015 Full text (in our servers)
  2. Salva P, Bianchetti G, Morselli P, Garcia-Teresa G, Costa J. Pharmacokinetics of alfuzosin after single oral administration to healthy volunteers, of three different doses. Biopharm Drug Dispos. 1992 Abstract

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