Last update Aug. 6, 2022

Alcuronium Chloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation. Intravenous administration.

At latest update, no relevant published data concerning excretion into breast milk were found.

Quaternary ammonium muscle relaxants are poorly absorbed from the gastro-intestinal tract; its low oral bioavailability renders the pass of this agent to the infant's plasma highly unlikely. (Dalal 2014, Spigset 1994)

Alcuronium does not prevent a mother from breast feeding her baby shortly after recovering from anesthesia if she is awake and in good condition.

Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

It is a product that is rarely used with very few bibliographic references. Other muscle relaxants with a more rapid elimination time period and better known drugs are preferred.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Alcuronium Chloride is also known as


Alcuronium Chloride in other languages or writings:

Group

Alcuronium Chloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Alcuronium Chloride in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 738 daltons
VD 0.1 - 0.3 l/Kg
3.3 hours

References

  1. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014 Abstract
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  3. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994 Abstract
  4. Ho PC, Stephens ID, Triggs EJ. Caesarean section and placental transfer of alcuronium. Anaesth Intensive Care. 1981 Abstract
  5. Walker J, Shanks CA, Triggs EJ. Clinical pharmacokinetics of alcuronium chloride in man. Eur J Clin Pharmacol. 1980 Abstract

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