Last update Sept. 18, 2022

Adenosine

Compatible

Safe substance and/or breastfeeding is the best option.

It is an endogenous adenine nucleoside, a component of nucleic acids and many coenzymes. It is used in the treatment of paroxysmal supraventricular tachycardia and in myocardial perfusion scintigraphy. Authorized use in Pediatrics, including newborns and infants. Administration by rapid intravenous injection.

Since the last update we have not found published data on its excretion in breastmilk.

It is rapidly absorbed into erythrocytes and vascular endothelial cells where it is metabolized to inosine and adenosine monophosphate (AMP). Its plasma half-life is so short (< 10 seconds) that it is highly unlikely that any of the drug will pass into breast milk. (Hale, Briggs 2015, Tan 2001)

Furthermore, its null oral bioavailability prevents the passage to the infant's plasma from ingested breast milk.

 

Alternatives

We do not have alternatives for Adenosine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Adenosine is also known as


Adenosine in other languages or writings:

Group

Adenosine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Adenosine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 267 daltons
pKa 12.45 -
0.003 hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Tan HL, Lie KI. Treatment of tachyarrhythmias during pregnancy and lactation. Eur Heart J. 2001 Abstract Full text (link to original source) Full text (in our servers)

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