Last update Oct. 24, 2023

Acrivastine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a second generation antihistamine related to triprolidine. It has minimal sedative or antimuscarinic actions.  It is used for symptomatic relief of allergic conditions such as rhinitis and urticaria. Oral administration three times a day. 

At the time of the last update we found no published data on its excretion in breast milk.

Its low molecular weight and low binding to plasma proteins facilitate excretion in breast milk, but its high volume of distribution makes it difficult.

Pending further published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Acrivastine in other languages or writings:

Group

Acrivastine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Acrivastine in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 348 daltons
Protein Binding 50 %
VD 0.46 ± 0.05 l/Kg
pKa 3.68 -
Tmax 1.1 ± 0.2 hours
1.4 - 3.5 hours

References

  1. Endo Ph. Semprex D (acrivastine & pseudoephedrine). Drug Summary. 2018 Full text (in our servers)
  2. del Cuvillo A, Mullol J, Bartra J, Dávila I, Jáuregui I, Montoro J, Sastre J, Valero AL. Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol. 2006;16 Suppl 1:3-12. Review. No abstract available. Abstract Full text (link to original source) Full text (in our servers)

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